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. 2018 Aug 31;293(42):16307–16323. doi: 10.1074/jbc.RA118.002887

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© 2018 Ho and Lin.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 6. — Positive correlation between the expression of EGFR and RNF144A in several types of cancer. A and B, Pearson correlation coefficients (r) between the mRNA expression (A) or protein expression (B) of EGFR and that of RNF144A in TCGA database (data extracted from xena.ucsc.edu). LumA, luminal A subtype breast cancer; LumB, luminal B subtype breast cancer. The correlations in some cancer types are also shown as scatter plots. x axis, RNF144A-gene expression RNAseq-IlluminaHiSeq pancan normalized; Unit, pan-cancer normalized log2(norm_count+1); y axis, EGFR-gene expression RNAseq-IlluminaHiSeq pancan normalized; Unit, pan-cancer normalized log2(norm_count+1). The pancan-normalized dataset subtracts out the mean expression across all cancer types and shows which genes are up-regulated or down-regulated compared with all other tissues. B, scatter plots show the correlation between EGFR protein levels and RNF144A transcript levels in luminal A and luminal B breast cancers. x axis, RNF144A-gene expression RNAseq-IlluminaHiSeq pancan normalized; Unit, Pan-cancer normalized log2(norm_count+1); y axis, EGFR-protein expression RPPA-RPPA; unit, normalized RPPA value.