Table I.
Comparison of biochemical parameters measured in liver tissue.
| Parameters | Group | Median | Minimum | Maximum | P |
|---|---|---|---|---|---|
| MDA (nmol/gr wet tissue) | Controla | 659.9 | 592.9 | 854.2 | 0.001 |
| Dexpb | 512.5 | 197.6 | 629.8 | ||
| Cisc | 1334.9 | 783.9 | 1999.9 | ||
| Cis+Dexpd | 904.5 | 673.3 | 1139 | ||
| GSH (nmol/gr wet tissue) | Controla | 2035.2 | 1781.9 | 2140.9 | 0.001 |
| Dexpb | 2769.1 | 2602.4 | 3198.6 | ||
| Cisc | 1612.1 | 1346.1 | 1865.3 | ||
| Cis+Dexpa | 2019.1 | 1852.5 | 2506.3 | ||
| CAT (K/g protein) | Controla | 24.1 | 20.1 | 30.3 | 0.001 |
| Dexpb | 51.4 | 48.4 | 57.2 | ||
| Cisc | 13.2 | 12.3 | 15.9 | ||
| Cis+Dexpd | 30.7 | 25.3 | 39.2 | ||
| GSH-Px (U/g protein) | Controla | 101.1 | 90.0 | 118.3 | 0.001 |
| Dexpa | 107 | 95.9 | 125.9 | ||
| Cisb | 59.8 | 45.4 | 95.47 | ||
| Cis+Dexpa | 89.2 | 71.8 | 108.1 | ||
| Tot Nit (nmol/gr wet tissue) | Controla | 275.4 | 266.4 | 298.8 | 0.001 |
| Dexpb | 349.2 | 288 | 381.6 | ||
| Cisc | 248.4 | 216 | 273.6 | ||
| Cis+Dexpd | 298.8 | 266.4 | 324 | ||
| TAS (mmol Trolox Eqv/l) | Controla | 2.2 | 2.1 | 2.54 | 0.001 |
| Dexpb | 2.5 | 2.4 | 2.6 | ||
| Cisc | 1.8 | 1.7 | 1.85 | ||
| Cis+Dexpa | 2.1 | 1.9 | 2.31 | ||
| TOS (µmol H2O2 Eqv/l) | Controla | 26.2 | 19.5 | 33.8 | 0.001 |
| Dexpa | 24.1 | 20.1 | 31.8 | ||
| Cisb | 39.1 | 35.2 | 46.4 | ||
| Cis+Dexpc | 33.3 | 26.2 | 35.1 | ||
| OSI (µmol H2O2 Eqv/mmol Trolox Eqv) | Controla | 11.9 | 7.7 | 15.6 | 0.001 |
| Dexpa | 9.7 | 7.8 | 13.1 | ||
| Cisb | 21.8 | 20.1 | 25.9 | ||
| Cis+Dexpc | 15.5 | 11.5 | 16.8 | ||
| IL-1β (pg/ml) | Controla | 23.3 | 18.4 | 42.8 | 0.081 |
| Dexpa | 16.4 | 12.9 | 67.7 | ||
| Cisa | 26.8 | 19.4 | 63.4 | ||
| Cis+Dexpa | 35.9 | 20.5 | 41.7 | ||
| IL-6 (pg/ml) | Controla | 13.8 | 5.8 | 20.5 | 0.017 |
| Dexpa | 11.7 | 4.5 | 20.1 | ||
| Cisb | 28.8 | 13.8 | 60.1 | ||
| Cis+Dexpa | 17.1 | 6.3 | 34.6 | ||
| TNF-α (pg/ml) | Controla | 263.6 | 167.7 | 332.4 | 0.322 |
| Dexpa | 237.7 | 141.5 | 300.1 | ||
| Cisa | 293.6 | 219.5 | 441.6 | ||
| Cis+Dexpa | 242.4 | 222.4 | 361.9 |
a-c
Different superscript letters indicate that there is statistical difference between the groups (stepwise step-down multiple comparisons after significant Kruskal Wallis test; P<0.05). a-cSame superscript letters indicate that there is no statistical difference between the groups (P>0.05). Cis, cisplatin; Dexp, dexpanthenol; MDA, malondialdehyde; GSH, reduced glutathione; CAT, catalase; GSH-Px, glutathione peroxidase; Tot Nit, total nitrite; TAS, total antioxidant status; TOS, total oxidant status; OSI, oxidative stress index; ADMA, asymmetric dimethylarginine; SDMA, symmetric dimethylarginine.