Table II.
Comparison of biochemical parameters measured in serum samples.
| Parameters | Groups | Median | Minimum | Maximum | P |
|---|---|---|---|---|---|
| GSH (µmol/l) | Controla | 15.9 | 15.7 | 16,3 | 0.014 |
| Dexpb | 19.2 | 17.3 | 19,4 | ||
| Cisa | 15.9 | 14.3 | 17,1 | ||
| Cis+Dexpb | 17.7 | 16.3 | 19,1 | ||
| TAS (mmol Trolox Eqv/l) | Controla | 1.3 | 1.3 | 1.3 | 0.003 |
| Dexpb | 1.7 | 1.4 | 1.9 | ||
| Cisc | 1.1 | 1.1 | 1.1 | ||
| Cis+Dexpb | 1.6 | 1.4 | 1.6 | ||
| TOS (µmol H2O2 Eqv/l) | Controla | 41.2 | 38.8 | 42.8 | 0.058 |
| Dexpa | 35.2 | 32.4 | 38.4 | ||
| Cisa | 49.6 | 33.6 | 55.6 | ||
| Cis+Dexpa | 44.4 | 37.6 | 44.8 | ||
| OSI (µmol H2O2 Eqv/mmol trolox Eqv) | Controla | 32.6 | 30.6 | 32.9 | 0.004 |
| Dexpb | 20.1 | 16.8 | 27.9 | ||
| Cisa | 47.1 | 30.9 | 54.3 | ||
| Cis+Dexpb | 27.2 | 26.9 | 27.3 | ||
| Tot Nit (µmol/l) | Controla | 33.9 | 32.9 | 34.8 | 0.003 |
| Dexpb | 45.2 | 44.3 | 48.0 | ||
| Cisa | 32.5 | 31.1 | 33.9 | ||
| Cis+Dexpc | 36.7 | 35.8 | 37.7 | ||
| L-Arjinin (µmol/l) | Controla | 0.5 | 0.3 | 0.7 | 0.003 |
| Dexpa | 0.4 | 0.3 | 0.5 | ||
| Cisb | 6.2 | 5.8 | 6.8 | ||
| Cis+Dexpc | 5.5 | 5.3 | 5.6 | ||
| ADMA (µmol/l) | Controla | 0.2 | 0,2 | 0.3 | 0.026 |
| Dexpa | 0.4 | 0,2 | 0.4 | ||
| Cisb | 0.5 | 0,2 | 0.6 | ||
| Cis+Dexpa | 0.2 | 0,1 | 0.3 | ||
| SDMA (µmol/l) | Controla | 0.5 | 0.4 | 0.5 | 0.022 |
| Dexpa | 0.4 | 0.3 | 0.5 | ||
| Cisb | 0.6 | 0.5 | 0.7 | ||
| Cis+Dexpa | 0.4 | 0.4 | 0.5 |
a-c
Different superscript letters indicate that there is statistical difference between the groups (Stepwise step-down multiple comparisons after significant Kruskal Wallis test; P<0.05).a-cSame superscript letters indicate that there is no statistical difference between the groups (P>0.05). Cis, cisplatin; Dexp, dexpanthenol; GSH, reduced glutathione; TAS, total antioxidant status; TOS, total oxidant status; OSI, oxidative stress index; Tot Nit, total nitrite; ADMA, asymmetric dimethylarginine; SDMA, symmetric dimethylarginine.