Table III.
Comparison of groups interms of histopathological and immunhistochemical findings.
| Parameters | Control | Dexp | Cis | Cis+Dexp |
|---|---|---|---|---|
| Congestion | ||||
| Median (min-max) | 1.0 (0.0–2.0) | 1.0 (0.0–2.0) | 1.0 (0.0–3.0)a | 1.0 (0.0–3.0)c |
| Mean ± SD | 0.56±0.58 | 0.70±0.60 | 1.13±0.66 | 1.30±0.60 |
| Glycogen loss | ||||
| Median (min-max) | 0.0 (0.0–3.0) | 0.0 (0.0–3.0) | 2.0 (0.0–3.0)a | 1.0 (0.0–2.0)b |
| Mean ± SD | 0.57±0.69 | 0.49±0.83 | 2.09±0.65 | 0.69±0.65 |
| Kupffer cells | ||||
| Median (min-max) | 1.0 (0.0–5.0) | 1.0 (0.0–6.0) | 5.0 (0.0–20.0)a | 1.0 (0.0–8.0)b |
| Mean ± SD | 1.35±1.30 | 1.22±1.50 | 5.46±3.79 | 1.63±1.60 |
| Caspase-3 expression | ||||
| Median (min-max) | 0.0 (0.0–1.0) | 0.0 (0.0–1.0) | 1.0 (0.0–3.0)a | 0.0 (0.0–1.0)b |
| Mean ± SD | 0.15±0.36 | 0.33±0.47 | 1.02±0.85 | 0.12±0.32 |
a
Cis vs. Control group (P<0.001)
b
Cis vs. Cis+Dex (P<0.001)
c
Cis vs. Cis+Dex (P<0.079). Cis, cisplatin; Dexp, dexpanthenol.