TABLE 1.

Fungal homeodomain proteins with a conserved interaction region

Phylum	Species	Description	Gene(s)	Phenotype	Reference(s)
Ascomycota	Candida albicans	Dimorphic yeast, human commensal and opportunistic pathogen	GRF10	grf10Δ shows filamentation defect; overexpressed GRF10 enhances filamentous growth; GRF10 is upregulated during biofilm development; Grf10 is required for transcription of genes in response to adenine starvation	11, 12, 15, 16
	Saccharomyces cerevisiae	Budding yeast, nonpathogen	PHO2	pho2Δ has sporulation defect and abnormal bud morphology; Pho2 regulates genes in response to phosphate and adenine starvation; Pho2 activates gene involved in initiation of mating type switching during vegetative cell division	22, 60, 61
	Schizosaccharomyces pombe	Fission yeast, nonpathogen	phx1+	Phx1 regulates long-term survival under nutrient starvation; phx1Δ shows meiotic sporulation defect; Phx1 regulates transcription of thiamine responsive genes	62, 63
	Neurospora crassa	Filamentous fungus, nonpathogen	Kal-1	Kal-1Δ exhibits delayed basal hyphal growth, defective conidiation; Kal-1 may have a role in nutrient sensing	64
	Podospora anserine	Filamentous fungus, nonpathogen	Pah1	Pah1 plays roles in hyphal morphogenesis and development of female ascogonia (microconidiogenesis)	65
	Botrytis cinerea	Plant pathogen	BcHOX8	Bchox8Δ exhibits a deformed morphology (arabesque), decreased conidial production, and attenuated virulence	66
	Yarrowia lipolytica	Dimorphic yeast	HOY1	hoy1Δ abolishes hyphal growth, while overexpressed HOY1 enhances filamentation	67
	Magnaporthe oryzae	Rice blast fungus, plant pathogen	MoHOX2 (HTF1), MoHOX7	MoHOX2 is required for conidiogenesis but not for appressorium-related pathogenic development; Mohox2Δ exhibits normal hyphal growth; MoHOX7 is required for normal appressoria formation	68, 69
	Aspergillus nidulans	Filamentous fungus, nonpathogen	RfeB	RfeB plays roles in asexual development, including hyphal growth and conidiation	70
Basidiomycota	Ustilago maydis	Corn smut, plant pathogen	UMAG04928	Hypothetical protein, uncharacterized phenotype	71
	Coprinopsis cinerea	Multicellular fungus, edible mushroom	CC1G_12380	Hypothetical protein, uncharacterized phenotype	72