Table III.
162 SNPs associated with coronary artery disease as determined by multivariable logistic regression analysis.
| Dominant model | Recessive model | |||||||
|---|---|---|---|---|---|---|---|---|
| Gene | SNP | P-value | OR | 95% CI | P-value | OR | 95% CI | |
| PLCB2 | rs200787930 | C/T | <0.0001 | 0.02 | 0.01–0.09 | |||
| MARCH1 | rs61734696 | G/T | <0.0001 | 0.02 | 0.01–0.10 | |||
| VPS33B | rs199921354 | C/T | <0.0001 | 0.02 | 0.01–0.09 | |||
| CXCL8 | rs188378669 | G/T | <0.0001 | 0.02 | 0.01–0.09 | |||
| TMOD4 | rs115287176 | G/A | <0.0001 | 0.02 | 0.01–0.10 | |||
| COL6A3 | rs146092501 | C/T | <0.0001 | 0.02 | 0.01–0.10 | |||
| ZNF77 | rs146879198 | G/A | <0.0001 | 0.02 | 0.01–0.10 | |||
| ADGRL3 | rs192210727 | G/T | <0.0001 | 0.07 | 0.03–0.16 | 0.9959 | ||
| OR52E4 | rs11823828 | T/G | <0.0001 | 1.66 | 1.41–1.97 | <0.0001 | 2.44 | 2.01–2.97 |
| ALDH2 | rs671 | G/A | <0.0001 | 1.73 | 1.50–2.01 | <0.0001 | 1.80 | 1.44–2.26 |
| ACAD10 | rs11066015 | G/A | <0.0001 | 1.73 | 1.49–2.01 | <0.0001 | 1.79 | 1.42–2.25 |
| BRAP | rs3782886 | A/G | <0.0001 | 1.71 | 1.48–1.99 | <0.0001 | 1.70 | 1.36–2.12 |
| HECTD4 | rs11066280 | T/A | <0.0001 | 1.73 | 1.49–2.01 | <0.0001 | 1.73 | 1.38–2.17 |
| HECTD4 | rs2074356 | C/T | <0.0001 | 1.61 | 1.39–1.87 | <0.0001 | 1.76 | 1.38–2.26 |
| NAA25 | rs12231744 | C/T | <0.0001 | 0.63 | 0.54–0.73 | <0.0001 | 0.55 | 0.43–0.70 |
| GOSR2 | rs1052586 | T/C | 0.0003 | 0.73 | 0.62–0.87 | <0.0001 | 0.64 | 0.53–0.77 |
| ATXN2 | rs7969300 | T/C | <0.0001 | 0.63 | 0.55–0.74 | <0.0001 | 0.57 | 0.45–0.71 |
| rs12229654 | T/G | <0.0001 | 1.46 | 1.26–1.69 | <0.0001 | 1.72 | 1.31–2.25 | |
| LOC107987429 | rs2844533 | T/C | <0.0001 | 1.36 | 1.17–1.59 | 0.8616 | ||
| MTFR2 | rs143974258 | G/A | 0.0014 | 0.04 | 0.01–0.28 | |||
| PSORS1C1 | rs3130559 | C/T | 0.0127 | 0.82 | 0.70–0.96 | 0.0629 | ||
| rs2596548 | G/T | <0.0001 | 1.76 | 1.41–2.20 | 0.2047 | |||
| EIF3L | rs9466 | T/C | 0.0053 | 1.24 | 1.07–1.44 | 0.0199 | 1.47 | 1.06–2.04 |
| LPGAT1 | rs150552771 | T/C | 0.9970 | <0.0001 | 2.20 | 1.83–2.64 | ||
| rs2523644 | A/G | <0.0001 | 1.59 | 1.31–1.92 | 0.9088 | |||
| rs10757278 | A/G | <0.0001 | 0.71 | 0.60–0.83 | 0.0023 | 0.77 | 0.65–0.91 | |
| CCHCR1 | rs130067 | T/G | 0.0010 | 0.78 | 0.68–0.91 | 0.0183 | 0.73 | 0.57–0.95 |
| TCHP | rs74416240 | G/A | 0.0002 | 1.35 | 1.15–1.58 | 0.1725 | ||
| rs1333049 | G/C | 0.0031 | 1.29 | 1.09–1.53 | <0.0001 | 1.41 | 1.20–1.66 | |
| CDKN2B-AS1 | rs4977574 | A/G | 0.0003 | 1.36 | 1.15–1.60 | <0.0001 | 1.43 | 1.21–1.69 |
| CDKN2B-AS1 | rs2383207 | G/A | <0.0001 | 0.75 | 0.65–0.87 | 0.0171 | 0.75 | 0.59–0.95 |
| SLC16A1 | rs1049434 | T/A | 0.0106 | 0.83 | 0.71–0.96 | <0.0001 | 0.57 | 0.45–0.73 |
| GIT2 | rs925368 | T/C | 0.0001 | 1.37 | 1.16–1.61 | 0.3189 | ||
| rs1333048 | A/C | 0.0036 | 1.29 | 1.09–1.53 | <0.0001 | 1.40 | 1.19–1.64 | |
| rs2523578 | T/C | <0.0001 | 1.55 | 1.27–1.88 | 0.8694 | |||
| rs404890 | G/T | 0.0005 | 1.29 | 1.12–1.50 | 0.0160 | 1.35 | 1.06–1.72 | |
| APOE | rs7412 | C/T | 0.0001 | 0.56 | 0.42–0.76 | 0.2259 | ||
| CCHCR1 | rs130071 | G/A | 0.0149 | 1.36 | 1.06–1.73 | 0.2668 | ||
| rs602633 | C/A | 0.0001 | 0.64 | 0.51–0.80 | 0.1782 | |||
| CELSR2 | rs12740374 | G/T | <0.0001 | 0.63 | 0.51–0.79 | 0.1708 | ||
| MKI67 | rs145121731 | G/A | 0.0014 | 1.94 | 1.29–2.91 | 0.9957 | ||
| CUBN | rs78201384 | C/T | 0.0003 | 0.50 | 0.34–0.73 | 0.9959 | ||
| PSORS1C3 | rs887466 | T/C | 0.0013 | 1.29 | 1.11–1.52 | 0.1666 | ||
| PSORS1C1 | rs3094663 | G/A | <0.0001 | 1.41 | 1.21–1.63 | 0.6404 | ||
| rs10853110 | A/G | 0.0026 | 1.26 | 1.09–1.47 | 0.0102 | 1.29 | 1.06–1.56 | |
| WDR37 | rs10794720 | C/T | 0.0003 | 0.68 | 0.55–0.84 | 0.0734 | ||
| CELSR2 | rs629301 | A/C | 0.0002 | 0.65 | 0.52–0.82 | 0.1708 | ||
| SKIV2L | rs592229 | G/T | 0.0154 | 1.22 | 1.04–1.42 | 0.0138 | 1.26 | 1.05–1.51 |
| rs12182351 | T/C | 0.0008 | 1.28 | 1.11–1.48 | 0.0138 | 1.37 | 1.07–1.75 | |
| POU5F1 | rs3130503 | G/A | <0.0001 | 1.41 | 1.22–1.63 | 0.6308 | ||
| PSORS1C3 | rs1265155 | T/C | 0.0017 | 1.29 | 1.10–1.50 | 0.1666 | ||
| CELSR2 | rs646776 | A/G | 0.0002 | 0.65 | 0.52–0.82 | 0.2660 | ||
| rs2596503 | C/T | 0.0204 | 1.19 | 1.03–1.38 | 0.1828 | |||
| TRPM1 | rs2241493 | T/C | 0.0002 | 0.71 | 0.60–0.85 | 0.0410 | 0.49 | 0.25–0.97 |
| CCDC141 | rs13419085 | T/C | 0.0005 | 0.43 | 0.27–0.69 | |||
| VARS2 | rs9394021 | A/G | 0.0261 | 0.82 | 0.69–0.98 | 0.0117 | 0.81 | 0.69–0.95 |
| SFTA2 | rs2286655 | T/C | 0.0097 | 1.24 | 1.05–1.45 | 0.0277 | 1.22 | 1.02–1.45 |
| rs3873334 | T/C | 0.0117 | 1.23 | 1.05–1.44 | 0.0261 | 1.22 | 1.02–1.45 | |
| TCF19 | rs3130453 | C/T | 0.0077 | 0.82 | 0.71–0.95 | 0.0024 | 0.68 | 0.53–0.87 |
| DDR1 | rs2239518 | T/C | 0.0103 | 1.23 | 1.05–1.45 | 0.0282 | 1.22 | 1.02–1.45 |
| CDSN | rs3130984 | C/T | <0.0001 | 1.39 | 1.18–1.64 | 0.1220 | ||
| rs197932 | T/C | 0.0042 | 0.81 | 0.70–0.93 | 0.0348 | 0.73 | 0.54–0.98 | |
| CDSN | rs3130981 | C/T | <0.0001 | 1.39 | 1.18–1.64 | 0.1226 | ||
| MICB-DT | rs3132469 | C/T | <0.0001 | 1.63 | 1.30–2.05 | 0.3960 | ||
| HLA-DQB1 | rs1049056 | C/A | 0.0050 | 1.28 | 1.08–1.52 | 0.1586 | ||
| DDR1 | rs2239517 | A/G | 0.0115 | 1.23 | 1.05–1.44 | 0.0326 | 1.21 | 1.02–1.44 |
| CCHCR1 | rs1265110 | G/A | 0.0096 | 0.83 | 0.71–0.95 | 0.0948 | ||
| CCDC63 | rs10774610 | T/C | 0.0006 | 1.29 | 1.12–1.49 | 0.0214 | 1.38 | 1.05–1.82 |
| GTF2H4 | rs2284176 | C/T | 0.0153 | 1.22 | 1.04–1.43 | 0.0306 | 1.21 | 1.02–1.45 |
| GTF2H4 | rs3909130 | G/A | 0.0138 | 1.22 | 1.04–1.43 | 0.0326 | 1.21 | 1.02–1.44 |
| GTF2H4 | rs916920 | G/A | 0.0139 | 1.22 | 1.04–1.43 | 0.0326 | 1.21 | 1.02–1.44 |
| rs1264569 | A/G | 0.0004 | 1.54 | 1.21–1.97 | 0.5339 | |||
| rs9468845 | A/G | 0.0141 | 1.22 | 1.04–1.43 | 0.0332 | 1.21 | 1.02–1.44 | |
| DDR1 | rs8408 | C/T | 0.0141 | 1.22 | 1.04–1.43 | 0.0326 | 1.21 | 1.02–1.44 |
| DDR1 | rs7756521 | C/T | 0.0155 | 1.22 | 1.04–1.43 | 0.0303 | 1.21 | 1.02–1.45 |
| CDKN2B-AS1 | rs1011970 | G/T | 0.0047 | 1.36 | 1.10–1.69 | 0.2199 | ||
| ADAT1 | rs145161932 | T/C | 0.0104 | 0.48 | 0.27–0.84 | 0.9960 | ||
| POU5F1 | rs885950 | T/G | 0.0049 | 0.81 | 0.70–0.94 | 0.0129 | 0.73 | 0.57–0.94 |
| DDR1 | rs4618569 | A/G | 0.0141 | 1.22 | 1.04–1.43 | 0.0333 | 1.21 | 1.02–1.44 |
| KRT13 | rs146918776 | A/G | <0.0001 | 2.21 | 1.50–3.26 | |||
| rs2523638 | G/A | 0.0197 | 1.20 | 1.03–1.41 | 0.1032 | |||
| PSRC1 | rs599839 | A/G | 0.0004 | 0.67 | 0.54–0.83 | 0.1023 | ||
| rs9275141 | G/T | 0.0134 | 1.20 | 1.04–1.39 | 0.0065 | 1.43 | 1.11–1.85 | |
| CCDC63 | rs10849915 | T/C | 0.0005 | 1.30 | 1.12–1.50 | 0.0458 | 1.33 | 1.01–1.76 |
| HLA-DRA | rs3177928 | G/A | <0.0001 | 1.58 | 1.27–1.96 | 0.7635 | ||
| OAS3 | rs2072134 | C/T | 0.0004 | 1.31 | 1.13–1.53 | 0.0268 | 1.51 | 1.05–2.16 |
| USP45 | rs41288947 | C/G | 0.0002 | 1.35 | 1.15–1.58 | 0.1360 | ||
| CCHCR1 | rs1265109 | A/C | 0.0007 | 1.35 | 1.14–1.61 | 0.0334 | 1.20 | 1.01–1.41 |
| LOC101929163 | rs6930777 | C/T | <0.0001 | 1.60 | 1.28–2.00 | 0.9815 | ||
| rs7333181 | G/A | 0.0219 | 0.64 | 0.44–0.94 | 0.9969 | |||
| DDR1 | rs1264323 | T/C | 0.0240 | 1.19 | 1.02–1.39 | 0.0423 | 1.22 | 1.01–1.48 |
| LINC00243 | rs3094111 | G/A | 0.0061 | 1.24 | 1.06–1.45 | 0.5293 | ||
| rs10484561 | T/G | <0.0001 | 1.59 | 1.28–1.98 | 0.7637 | |||
| PSORS1C1 | rs3130558 | G/C | <0.0001 | 1.39 | 1.18–1.64 | 0.2712 | ||
| HLA-DQB1 | rs1049060 | T/A | 0.0676 | 0.0077 | 1.38 | 1.09–1.75 | ||
| rs2844650 | G/A | <0.0001 | 1.66 | 1.30–2.11 | 0.4729 | |||
| DDR1 | rs3132572 | T/C | <0.0001 | 1.66 | 1.30–2.11 | 0.4729 | ||
| CCHCR1 | rs1265115 | T/G | 0.0004 | 1.36 | 1.15–1.62 | 0.0443 | 1.19 | 1.00–1.40 |
| CCHCR1 | rs3094225 | T/C | <0.0001 | 1.46 | 1.23–1.74 | 0.5822 | ||
| LOC107987453 | rs3129987 | C/T | 0.0037 | 1.26 | 1.08–1.47 | 0.5667 | ||
| DPCR1 | rs2517451 | A/G | <0.0001 | 1.65 | 1.30–2.11 | 0.4729 | ||
| CCHCR1 | rs1265115 | T/G | 0.0004 | 1.36 | 1.15–1.62 | 0.0443 | 1.19 | 1.00–1.40 |
| CCHCR1 | rs3094225 | T/C | <0.0001 | 1.46 | 1.23–1.74 | 0.5822 | ||
| LOC107987453 | rs3129987 | C/T | 0.0037 | 1.26 | 1.08–1.47 | 0.5667 | ||
| DPCR1 | rs2517451 | A/G | <0.0001 | 1.65 | 1.30–2.11 | 0.4729 | ||
| KIAA1551 | rs10771894 | A/G | 0.1122 | 0.0085 | 1.35 | 1.08–1.69 | ||
| rs13427905 | C/T | 0.0024 | 0.78 | 0.67–0.92 | 0.1397 | |||
| ABCA1 | rs1883025 | G/A | 0.0051 | 0.81 | 0.70–0.94 | 0.0080 | 0.68 | 0.51–0.90 |
| SFTA2 | rs2253705 | G/A | 0.0015 | 1.28 | 1.10–1.48 | 0.6682 | ||
| PLUT | rs954750 | G/A | 0.0409 | 1.19 | 1.01–1.41 | 0.0008 | 1.33 | 1.12–1.57 |
| TCF19 | rs1419881 | T/C | 0.0009 | 1.34 | 1.13–1.60 | 0.0487 | 1.18 | 1.00–1.39 |
| rs13209234 | G/A | <0.0001 | 1.55 | 1.25–1.93 | 0.7617 | |||
| PSORS1C1 | rs1265100 | T/C | 0.0055 | 0.81 | 0.70–0.94 | 0.4135 | ||
| YEATS2 | rs76174573 | G/T | 0.0031 | 0.61 | 0.44–0.85 | 0.1756 | ||
| ABO | rs1053878 | C/T | 0.0033 | 1.25 | 1.08–1.44 | 0.1723 | ||
| rs4014195 | C/G | 0.0083 | 1.23 | 1.05–1.43 | 0.2586 | |||
| SFTA2 | rs2253588 | C/G | 0.0021 | 1.26 | 1.09–1.45 | 0.7016 | ||
| rs10757283 | T/C | 0.0079 | 0.82 | 0.71–0.95 | 0.0181 | 0.74 | 0.58–0.95 | |
| BTNL2 | rs28362680 | G/A | 0.1143 | 0.0082 | 0.76 | 0.62–0.93 | ||
| BTNL2 | rs10947262 | C/T | 0.1143 | 0.0082 | 0.76 | 0.62–0.93 | ||
| KRT27 | rs17558532 | C/T | 0.0004 | 0.57 | 0.41–0.78 | 0.5002 | ||
| GTF2H4 | rs3130780 | G/T | 0.0022 | 1.26 | 1.09–1.47 | 0.6706 | ||
| rs2532934 | T/C | 0.0023 | 1.25 | 1.08–1.45 | 0.5320 | |||
| VARS2 | rs753725 | G/A | 0.0021 | 1.26 | 1.09–1.45 | 0.5274 | ||
| PLUT | rs11619319 | A/G | 0.0482 | 1.18 | 1.00–1.40 | 0.0007 | 1.33 | 1.13–1.58 |
| rs3095273 | C/T | 0.0045 | 1.38 | 1.11–1.73 | 0.1778 | |||
| TNS1 | rs918949 | C/T | 0.0028 | 0.79 | 0.68–0.92 | 0.1301 | ||
| LINC00243 | rs3130785 | C/T | 0.0060 | 1.24 | 1.06–1.45 | 0.5417 | ||
| VARS2 | rs2249464 | C/T | 0.0028 | 1.25 | 1.08–1.44 | 0.5320 | ||
| rs3095345 | A/G | 0.0021 | 1.27 | 1.09–1.47 | 0.7469 | |||
| ITGB8 | rs80015015 | G/A | <0.0001 | 1.56 | 1.28–1.91 | 0.2511 | ||
| VARS2 | rs885905 | C/T | 0.0028 | 1.25 | 1.08–1.44 | 0.7687 | ||
| LIPE | rs34052647 | G/A | 0.0001 | 1.53 | 1.23–1.90 | 0.0074 | 3.70 | 1.42–9.65 |
| PHACTR1 | rs9369640 | A/C | 0.0025 | 0.73 | 0.60–0.90 | 0.1527 | ||
| BTNL2 | rs41417449 | T/C | 0.1641 | 0.0017 | 0.55 | 0.38–0.80 | ||
| BTNL2 | rs41441651 | C/T | 0.1586 | 0.0017 | 0.55 | 0.38–0.80 | ||
| BTNL2 | rs28362675 | C/A | 0.1584 | 0.0017 | 0.55 | 0.38–0.80 | ||
| BTNL2 | rs78587369 | G/A | 0.1590 | 0.0018 | 0.55 | 0.38–0.80 | ||
| BTNL2 | rs3763315 | G/T | 0.1637 | 0.0017 | 0.55 | 0.38–0.80 | ||
| BTNL2 | rs2076528 | T/G | 0.1524 | 0.0017 | 0.55 | 0.38–0.80 | ||
| PRKG1 | rs9414827 | G/A | 0.0003 | 0.70 | 0.58–0.85 | 0.0395 | 0.46 | 0.22–0.96 |
| rs6537384 | T/G | 0.0191 | 1.19 | 1.03–1.38 | 0.1787 | |||
| rs6067640 | G/A | 0.0323 | 0.85 | 0.73–0.99 | 0.0054 | 0.74 | 0.60–0.91 | |
| rs10514995 | A/G | 0.0467 | 1.19 | 1.00–1.42 | 0.0825 | |||
| BTNL2 | rs34423804 | T/A | 0.1675 | 0.0018 | 0.55 | 0.38–0.80 | ||
| PHACTR1 | rs9349379 | G/A | 0.0029 | 0.80 | 0.69–0.93 | 0.0820 | ||
| STIM1 | rs116855870 | A/G | 0.0133 | 1.76 | 1.13–2.76 | 0.9967 | ||
| ZNF142 | rs3821033 | C/T | 0.0015 | 1.32 | 1.11–1.57 | 0.3469 | ||
| LINC00354 | rs4907518 | G/A | 0.0138 | 0.82 | 0.70–0.96 | 0.0050 | 0.77 | 0.64–0.92 |
| TNS3 | rs11763932 | G/A | 0.0054 | 0.81 | 0.69–0.94 | 0.0018 | 0.73 | 0.60–0.89 |
| BTRC | rs2270439 | C/A | 0.0063 | 0.64 | 0.47–0.88 | 0.6622 | ||
| MIA3 | rs2936051 | A/G | 0.1239 | 0.0002 | 0.67 | 0.55–0.83 | ||
| rs6825911 | C/T | 0.0020 | 0.78 | 0.67–0.91 | 0.0446 | 0.83 | 0.70–1.00 | |
| VNN1 | rs2294757 | G/A | 0.2269 | 0.0334 | 0.79 | 0.63–0.98 | ||
| ZNF860 | rs140232911 | C/T | 0.0013 | 0.14 | 0.04–0.46 | |||
| rs838880 | C/T | 0.0338 | 1.20 | 1.01–1.41 | 0.0308 | 1.20 | 1.02–1.43 | |
| MIA3 | rs2936052 | A/G | 0.0927 | 0.0044 | 0.71 | 0.56–0.90 | ||
| DTNBP1 | rs2743868 | G/A | 0.0208 | 1.19 | 1.03–1.37 | 0.0941 | ||
| MON2 | rs11174549 | A/G | 0.0427 | 1.28 | 1.01–1.61 | 0.1917 | ||
| rs507666 | G/A | 0.0098 | 1.21 | 1.05–1.40 | 0.1384 | |||
| FAM170B | rs73302786 | G/T | 0.0003 | 1.62 | 1.25–2.11 | 0.6351 | ||
| PSORS1C3 | rs3131018 | G/T | 0.0002 | 1.35 | 1.15–1.58 | 0.9209 | ||
| PIEZO2 | rs35033671 | C/A | 0.0035 | 1.30 | 1.09–1.54 | 0.1909 | ||
| PANK1 | rs11185790 | G/A | 0.0065 | 1.26 | 1.07–1.48 | 0.0457 | 1.19 | 1.00–1.41 |
| GFY | rs73053944 | C/G | 0.0011 | 1.60 | 1.21–2.13 | 0.0698 | ||
| RNF2 | rs1046592 | A/G | 0.0301 | 0.85 | 0.74–0.98 | 0.7186 | ||
Multivariable logistic regression analysis was performed with adjustment for age, sex, and the prevalence of hypertension, diabetes mellitus and dyslipidemia. P<0.05 was considered to indicate a statistically significant difference. SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval.