Table VI.
Association between genes, chromosomal loci and SNPs associated with coronary artery disease in the present study and previously examined cardiovascular disease-related phenotypes.
| Gene/chr. locus | SNP | Chr. | Position | Previously examined phenotypes |
|---|---|---|---|---|
| 1p13.3 | rs602633 | 1 | 109278889 | CAD (23202125, 20032323), LDL-cholesterol (20686565, 23063622, 19060906, 21943158, 18193043, 18262040, 19913121, 21977987, 20339536), HDL-cholesterol (23063622, 20686565), total cholesterol (20686565, 23063622) |
| SLC16A1 | rs1049434 | 1 | 112913924 | HDL-cholesterol (23063622) |
| RNF2 | rs1046592 | 1 | 185100429 | None |
| MIA3 | rs2936051 | 1 | 222629862 | CAD (19198612, 21347282, 23364394, 21378990, 17554300, 22319020, 21966275), MI (19198609) |
| 2p13 | rs13427905 | 2 | 71846585 | None |
| CCDC141 | rs13419085 | 2 | 178837710 | Heart rate (23583979, 20639392), left ventricular mass (19584346) |
| TNS1 | rs918949 | 2 | 217809974 | Lung function, forced expiratory volume in |
| 1 second (20010834, 21946350, 23284291) | ||||
| YEATS2 | rs76174573 | 3 | 183804099 | None |
| 4q24 | rs6825911 | 4 | 110460482 | Systolic BP (21572416), diastolic BP (21572416) |
| 4q31.2 | rs6537384 | 4 | 145949613 | None |
| 5q12 | rs10514995 | 5 | 66443611 | None |
| PHACTR1 | rs9369640 | 6 | 12901209 | CAD (21378988, 23202125, 22745674, 21347282, 23364394, 21378990, 22751097, 22745674), MI (19198609, 21378990), ischemic stroke (22306652) |
| PSORS1C1 | rs3094663 | 6 | 31139310 | Type 1 diabetes (17554300, 17632545), triglycerides (20686565), total cholesterol (20686565) |
| CCHCR1 | rs130071 | 6 | 31148433 | Triglycerides (20686565) |
| 6p21.3 | rs2523644 | 6 | 31374707 | Type 1 diabetes (17554300, 17632545), LDL-cholesterol (23063622, 20686565), triglycerides (23063622, 20686565), total cholesterol (23063622, 20686565) |
| SKIV2L | rs592229 | 6 | 31962664 | CAD (21971053), type 1 diabetes (17554300, 17632545), LDL-cholesterol (20686565), triglycerides (20686565), total cholesterol (20686565) |
| USP45 | rs41288947 | 6 | 99446210 | None |
| ITGB8 | rs80015015 | 7 | 20401881 | None |
| TNS3 | rs11763932 | 7 | 47567880 | None |
| CDKN2B-AS1 | rs1011970 | 9 | 22062135 | CAD (21347282), LDL-cholesterol (23063622), abdominal aortic aneurysm (20622881), type 2 diabetes (17463249) |
| 9p21 | rs1333048 | 9 | 22125348 | CAD (23202125, 21606135, 19198612, 17634449, 20032323, 23364394), MI (17478679), intracranial aneurysm (22961961) |
| 9p21 | rs10757283 | 9 | 22134173 | Type 2 diabetes (20581827) |
| ABCA1 | rs1883025 | 9 | 104902020 | HDL-cholesterol (20686565, 23505323, 23063622, 21909109, 19060911, 21347282, 19060906, 18193043, 18193044, 18193046, 22629316, 20864672, 21347282, 23726366), LDL-cholesterol (20686565), total cholesterol (20686565, 23063622, 20339536) |
| 9q34.2 | rs507666 | 9 | 136149399 | Venous thrombosis (22675575), VLDL-cholesterol |
| small lipoprotein fraction concentration (19936222), LDL-cholesterol lipoprotein fraction concentration (19936222) | ||||
| WDR37 | rs10794720 | 10 | 1110225 | Estimated glomerular filtration rate (20383146, 22479191), serum creatinine (20383146) |
| CUBN | rs78201384 | 10 | 17111024 | LDL-cholesterol (23063622), HDL-cholesterol (23063622), total cholesterol (23063622) |
| FAM170B-AS1 | rs73302786 | 10 | 49131709 | None |
| PRKG1 | rs9414827 | 10 | 51137314 | None |
| PANK1 | rs11185790 | 10 | 89612776 | Insulin concentration (19060910) |
| BTRC | rs2270439 | 10 | 101550817 | None |
| MKI67 | rs145121731 | 10 | 128102595 | None |
| STIM1 | rs116855870 | 11 | 4055527 | None |
| OR52E4 | rs11823828 | 11 | 5884973 | None |
| 11q13.1 | rs4014195 | 11 | 65739351 | Serum urate (23263486), serum creatinine (20383146), estimated glomerular filtration rate (20383146) |
| KIAA1551 | rs10771894 | 12 | 31982009 | None |
| MON2 | rs11174549 | 12 | 62565357 | None |
| 12q24.1 | rs12229654 | 12 | 110976657 | HDL-cholesterol (21909109) |
| ALDH2 | rs671 | 12 | 111803962 | CAD (21971053, 21572416, 23202125), MI (21971053), LDL-cholesterol (21572416, 20686565), HDL-cholesterol |
| (21572416, 21372407), total cholesterol (20686565), systolic BP | ||||
| (21572416), diastolic BP (21572416, 21909115), serum creatinine | ||||
| (22797727), estimated glomerular filtration rate (22797727), type 1 diabetes (17554300) | ||||
| HECTD4 | rs2074356 | 12 | 112207597 | CAD (21971053, 21572416, 22751097, 19820697, 23364394, 23202125), MI (19820697), LDL-cholesterol (21572416, 20686565), HDL-cholesterol (21572416, 21909109, 22751097), total cholesterol |
| (20686565), systolic BP (21572416, 21909115), diastolic BP | ||||
| (21572416, 21909115, 19862010, 19430479, 22751097), hypertension (21572416), serum creatinine (22797727), estimated | ||||
| glomerular filtration rate (22797727), type 1 diabetes (18978792) | ||||
| 12q24.31 | rs838880 | 12 | 124777047 | HDL-cholesterol (20686565) |
| PLUT | rs954750 | 13 | 27889801 | None |
| 13q34 | rs7333181 | 13 | 111568950 | None |
| LINC00354 | rs4907518 | 13 | 111898209 | None |
| TRPM1 | rs2241493 | 15 | 31070149 | None |
| PLCB2 | rs200787930 | 15 | 40289298 | Triglycerides (23063622) |
| ADAT1 | rs145161932 | 16 | 75612670 | None |
| KRT27 | rs17558532 | 17 | 40779624 | None |
| 17q21.3 | rs197932 | 17 | 46896981 | Pulse pressure (21909110), systolic BP (21909110, 21909115) |
| GOSR2 | rs1052586 | 17 | 46941097 | Pulse pressure (21909110), systolic BP (21909110, 21909115) |
| LIPE | rs34052647 | 19 | 42407617 | None |
| APOE | rs7412 | 19 | 44908822 | LDL-cholesterol (23100282, 23063622, 20686565, 22629316, 19060911, 23067351, 23696881, 20838585), HDL-cholesterol |
| (21386085), triglycerides (23063622, 20686565, 22629316, 19060911, 21386085), total cholesterol (23063622, 20686565) | ||||
| GFY | rs73053944 | 19 | 49427038 | None |
| 20q13.2 | rs6067640 | 20 | 51092837 | None |
| EIF3L | rs9466 | 22 | 37877742 | None |
Data were obtained from the GRASP Search database (https://grasp.nhlbi.nih.gov/Search.aspx) with a P-value of <1.0×10−6. Numbers in parentheses are PubMed IDs. SNP, single nucleotide polymorphisms; Chr., chromosome; HDL, high density lipoprotein; LDL, low density lipoprotein; CAD, coronary artery disease; MI, myocardial infarction; BP, blood pressure.