FIG 8.

Crystal structures of FKBP12 and alignment of FKBP12 sequences. (A) Superimposition of the FKBP12-FK506 structures of Homo sapiens (PDB accession number 1FKJ), C. albicans (PDB accession number 5HW8), and A. fumigatus (PDB accession number 5HWC). (B) Sequence alignments of the FKBP12s of H. sapiens, C. neoformans, C. albicans, and A. fumigatus. The secondary structure of FKBP12 is shown above the sequence. Key residues for binding between FKBP12 and FK506 are labeled with a box. Identical and highly conserved residues are highlighted in orange and yellow, respectively. (C) Binding mode of FK506 within the hydrophobic pocket of human FKBP12 (PDB accession number 1FKJ).