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Observed zidebactam (ZID) free plasma and epithelial lining fluid (ELF) concentrations in the neutropenic lung infection model following dosing of the zidebactam human-simulated regimen (22.5 mg/kg at 0 h, 4.5 mg/kg at 2 h, 2.5 mg/kg at 4 h, and 1.5 mg/kg at 6 h, every 8 h) and the cefepime human-simulated regimen compared with the simulated human zidebactam exposure following a 1-g 1-hour intravenous infusion.
