TABLE 2.
Comparison of %fT>MIC values achieved in human plasma and murine plasma after treatmenta
| MIC (μg/ml) | Plasma %fT>MIC for: |
|||
|---|---|---|---|---|
| Cefepime |
Zidebactam |
|||
| Humans | Mice | Humans | Mice | |
| 4 | 100.00 | 100.00 | 92.50 | 92.50 |
| 8 | 92.92 | 92.50 | 67.50 | 70.00 |
| 16 | 66.25 | 66.25 | 42.08 | 41.25 |
| 32 | 41.25 | 41.25 | 19.17 | 20.42 |
| 64 | 18.33 | 19.58 | 0.00 | 3.75 |
| 128 | 0.00 | 0.00 | 0.00 | 0.00 |
a
Cefepime (2 g) and zidebactam (1 g) were administered to humans intravenously over 1 h every 8 h in a phase 1 study. Human-simulated regimens were administered subcutaneously to mice.