FIG 3.

Survival curves for mice inoculated intracranially with C. neoformans and treated with VT-1129. Treatment with oral therapy started 1 day postinoculation and continued for 10 days, after which mice were monitored without therapy until day 30. (A and B) Two independent experiments from the survival arm, with 10 mice per group per experiment. Black squares, vehicle control; gray circles, 1-mg/kg loading dose of VT-1129 on day 1 and 0.15-mg/kg daily maintenance doses thereafter; times signs, 3-mg/kg loading dose of VT-1129 on day 1 and 0.5-mg/kg daily maintenance doses thereafter; white diamonds, 30-mg/kg loading dose of VT-1129 on day 1 and 5-mg/kg daily maintenance doses thereafter; gray triangles, daily VT-1129 dose of 10 mg/kg.