FIG 4.

Brain tissue fungal burdens in mice with cryptococcal meningitis secondary to C. neoformans. (A) Brain tissue fungal burdens in mice in the fungal burden arm experiments. Treatment with oral therapy started 1 day postinoculation and continued for 14 days. CFU in brain tissue were measured on day 15 postinoculation. (B) Brain tissue fungal burdens in mice in the survival arm experiments. Treatment with oral therapy started 1 day postinoculation and continued for 10 days. Mice were monitored without therapy until day 30. CFU in brain tissue were measured on day 30 postinoculation or as the mice succumbed to infection. Combined results of two independent experiments, with 20 mice per group, are shown. Horizontal lines represent mean values. LD, loading dose; MD, maintenance dose. Light gray circles, CFU detected after vacuum filtration and washing to remove residual VT-1129; times signs, no fungal burden detected by any method. *, P < 0.001; **, P < 0.0001.