FIG 3.

Key amino acid residues in the LBP of ScLDM. (A) Amino acid residues in the active site of ScLDM conserved among fungal pathogens and their human and plant hosts. The side chains of the conserved amino acid residues are shown in yellow. The carbons of lanosterol and the heme are shown in green and cyan, respectively, nitrogens are blue, oxygens are red, and iron is orange. (B) Amino acid residues in the LBP conserved among ascomycete and basidiomycete pathogens not found in human or plant hosts and not subject to known mutations. The surface of the LBP is shown. Heme carbons are shown in cyan, ITC carbons in green, and the side chain carbons of residues of interest in yellow. Nitrogens are shown in blue, oxygen in red, and iron in orange.