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Model simulation. (a) PK model results. The concentrations of DHA (blue), PPQ (red), and MQ (black) are depicted. The shaded regions show the area between the 2.5th and 97.5th percentiles of the results generated for 1,000 patients. (b) PD model results for 100 randomly selected patients. The horizontal line shows the microscopic level of detection of parasites. (c) Kaplan-Meier estimation of the probability of survival over 42 days of follow-up.
