FIG 7.

Latency reversal of Ing M, Ing 3-R, and αCD3/CD28. (A) Despite structural similarities between Ing M and Ing 3-R, paired analysis of nine independent ex vivo experiments comparing fold change increases in cell-associated viral transcripts in resting CD4⁺ T cells from aviremic HIV-1-positive participants demonstrated a statistically significant difference favoring Ing 3-R (Wilcoxon matched-pairs signed-rank test, P < 0.005; n = 9). (B) The same paired analysis comparing fold change increases in cell-associated viral transcripts between Ing 3-R and positive control (αCD3/CD28) did not reveal any statistically significant difference between these conditions (Wilcoxon matched-pairs signed-rank test, P = 0.25; n = 9).