FIG 4.

IL-10 levels in M. tuberculosis-infected macrophages treated with first-line antibiotics in the presence and absence of NAC. IL-10 was measured using an ELISA Ready-Set-Go kit from eBioscience. Although there was a decrease in the levels of IL-10 when M. tuberculosis-infected macrophages were treated with NAC, INH, INH plus NAC, RIF, RIF plus NAC, and EMB plus NAC, this difference was not found to be statistically significant. There was a significant decrease in the levels of IL-10 when macrophages were infected with M. tuberculosis and treated with PZA plus NAC and a slight decrease when samples were treated with PZA (not significant). Data represent the means ± SE from 6 trials. (B) Correlation between IL-10 production and M. tuberculosis survival inside untreated, NAC-treated, INH-treated, INH- and NAC-treated, RIF-treated, RIF- and NAC-treated, EMB-treated, EMB- and NAC-treated, PZA-treated, and PZA- and NAC-treated macrophages.