TABLE 2.
In vitro azole susceptibility profile and polymorphism in cyp51A and its orthologs of six isolates included in the expression study
| Isolate | MIC fora: |
Mutation(s) in gene target: |
||||
|---|---|---|---|---|---|---|
| VOR | ITR | POS | cyp51A | cyp51B | cyp51C | |
| NCCPF761476 | 8 | 16 | 0.125 | A205T | M54T and S240A | |
| NCCPF761488 | 4 | 0.5 | 0.125 | A205T | M54T and S240A | |
| NCCPF761157 | 4 | 16 | 0.25 | A205T | M54T, S240A, D254N, I285V, and Y319H | |
| NCCPF761267 | 0.5 | 0.12 | 0.06 | A205T | M54T and S240A | |
| NCCPF760690 | 0.125 | 0.06 | 0.03 | A205T | M54T and S240A | |
| ATCC 204304 | 1 | 0.12 | 0.03 | A205T | NAb | |
a
VOR, voriconazole; ITR, itraconazole; and POS, posaconazole.
b
NA, not applicable.