TABLE 2.
B. burgdorferi N40 cultures from skin and DNA copies from bladder of both wild-type and SCID mice after 5 days of treatmenta
| WT treatment group | Whole-ear culture resultb | No. of bladder DNA copiesc |
|---|---|---|
| WT | ||
| Saline | + | 40 |
| + | 25 | |
| + | 20 | |
| + | 32 | |
| + | 105 | |
| + | 53 | |
| Doxycycline | − | 0 |
| − | 0 | |
| − | 0 | |
| − | 0 | |
| − | 0 | |
| − | 0 | |
| Ceftriaxone | − | 0 |
| − | 0 | |
| − | 0 | |
| − | 0 | |
| − | 0 | |
| − | 0 | |
| Vancomycin | − | 0 |
| − | 0 | |
| − | 0 | |
| − | 0 | |
| − | 0 | |
| − | 0 | |
| SCID | ||
| Saline | + | 609 |
| + | 1,032 | |
| + | 1,043 | |
| + | 1,667 | |
| + | 1,776 | |
| + | 1,327 | |
| Doxycycline | + | 7 |
| + | 9 | |
| + | 9 | |
| − | 6 | |
| − | 0 | |
| + | 4 | |
| Ceftriaxone | − | 0 |
| − | 0 | |
| − | 0 | |
| − | 0 | |
| − | 0 | |
| − | 0 | |
| Vancomycin | − | 0 |
| − | 0 | |
| − | 0 | |
| − | 0 | |
| − | 0 | |
| − | 0 |
a
The following doses were given every 12 h for 5 days: doxycycline, 50 mg/kg; ceftriaxone, 156 mg/kg; and vancomycin, 110 mg/kg.
b
+, B. burgdorferi cells were detected in the culture; −, no B. burgdorferi cells were detected in the culture.
c
DNA copies were normalized to 200 ng of tissue DNA.