TABLE 3.
B. burgdorferi N40 cultures from ear punches during antibiotic treatment in wild-type and SCID mouse infection modelsa
| Mouse group | Treatment group | No. with positive ear punch culture |
|||
|---|---|---|---|---|---|
| Day 1 | Day 2 | Day 3 | Day 4 | ||
| WT | Saline | 5 | 4 | 4 | 5 |
| Doxycycline | 1 | 0 | 0 | 0 | |
| Ceftriaxone | 0 | 0 | 0 | 0 | |
| Vancomycin | 0 | 0 | 0 | 0 | |
| SCID | Saline | 6 | 4 | 4 | 6 |
| Doxycycline | 6 | 5 | 4 | 4 | |
| Ceftriaxone | 0 | 0 | 0 | 0 | |
| Vancomycin | 0 | 0 | 0 | 0 | |
a
The following doses were given every 12 h for 5 days: doxycycline, 50 mg/kg; ceftriaxone, 156 mg/kg; and vancomycin, 110 mg/kg. n = 6 per treatment group.