TABLE 4.

B. burgdorferi N40 cultures from skin and DNA copies from tissues of SCID mice after one or two doses of 110 mg/kg vancomycin or 156 mg/kg ceftriaxone^a

Treatment group	Whole-ear culture resultb	No. of DNA copies inc:
		Spleen	Bladder	Heart
Ceftriaxone, 1 dose	−	14	38	309
	+	55	870	132
	+	0	30	136
	+	72	11	177
	+	38	56	189
	+	38	800	99
	−	46	14	80
Ceftriaxone, 2 doses	−	24	26	182
	+	382	368	95
	−	48	13	10
	−	48	80	96
	−	95	80	131
	−	0	0	204
	−	12	12	48
Vancomycin, 1 dose	−	53	0	0
	−	0	0	0
	−	0	0	0
	+	12	15	258
	+	5	104	128
	+	22	97	370
	−	9	12	14
Vancomycin, 2 doses	−	35	0	0
	−	0	0	44
	+	138	48	367
	−	0	0	0
	−	0	0	0
	−	0	26	60
	−	67	10	40

^aMice were sacrificed 24 h after the second dose.

^b+, B. burgdorferi cells were detected in the culture; −, no B. burgdorferi cells were detected in the culture.

^cDNA copies were normalized to 200 ng of tissue DNA.