FIG 3.

Multidimensional scatterplot of P. berghei Ookluc activity compared to P. falciparum gametocyte (stage IV and V) inhibition. The comparative activity of the MMV Pathogen Box compounds, previously screened as part of the MMV Malaria Box, is shown. The data represent the percent inhibition of the compounds utilizing the Ookluc assay screened at a single 10 μM concentration compared to the percent inhibitory activity, again at a single 10 μM concentration, against P. falciparum late-stage gametocytes (stages IV and V) (26). Colors reflect the growth inhibition level against P. falciparum 3D7 asexual parasites screened at 10 µM compound concentration, from blue (0% growth inhibition) to red (100% growth inhibition) (grey indicates no value). The symbols indicate the different annotated disease sets within the Pathogen Box.