Table 4.
Analysis of the Predictors Associated With Therapy Success vs Failure
| Characteristic | Univariate Analysis | Multivariate Analysis | |||
|---|---|---|---|---|---|
| Success (n = 76) | Failure (n = 51) | P Value | OR (95% CI) | P Value | |
| Age, median (range), y | 54 (4–80) | 56 (7–88) | .19 | ||
| Male sex | 53 (70) | 28 (55) | .09 | ||
| Race/ethnicity | .002 | ||||
| White | 47 (62) | 17 (33) | |||
| African American | 10 (13) | 5 (10) | |||
| Hispanic | 8 (11) | 8 (16) | |||
| Other | 11 (14) | 21 (41) | |||
| Type of cancer | .019 | ||||
| Hematological malignancy | 33 (43) | 33 (65) | |||
| Solid tumor | 43 (57) | 18 (35) | |||
| Steroids within 30 d of bacteremia | 18 (24) | 24 (47) | .006 | ||
| S. aureus methicillin susceptibility | .004 | ||||
| MRSA | 28 (37) | 32 (63) | |||
| MSSA | 48 (63) | 19 (37) | |||
| Neutropenia (ANC <500 cells/µL) at bacteremia | 9 (12) | 20 (39) | <.001 | ||
| Platelet count <50 at bacteremia | 14 (18) | 24 (47) | <.001 | ||
| Required ICU admission | 10 (13) | 17 (33) | .006 | 2.74 (1.08–6.99) | .034 |
| Catheter removal/exchange within 2 d of bacteremia | 53 (70) | 26 (51) | .033 | ||
| Deep-seated infections before or during IV antibiotic therapy | 10 (13) | 11 (22) | .21 | ||
| Time between bacteremia and imaging test, median (range), d | 3 (–4 to 45) | 4 (–4 to 34) | .07 | ||
| Type of thrombosis | .63 | ||||
| Deep veins | 65 (86) | 42 (82) | |||
| Superficial veins | 11 (14) | 9 (18) | |||
| Anticoagulation | 62 (82) | 25 (49) | <.001 | 0.24 (0.11–0.54) | <.001 |
One patient was excluded from analysis as he was nonevaluable for the outcome due to being lost to follow-up. The probability modeled in multivariate analysis was for “Failure” of the outcome. Only factors that were independently associated with the outcome (P < .05) by univariate analysis were shown in multivariate analysis.
Abbreviations: ANC, absolute neutrophil count; CI, confidence interval; ICU, intensive care unit; IV, intravenous; MRSA, methicillin-resistant Staphylococcus aureus; MSSA, methicillin-sensitive Staphylococcus aureus; OR, odds ratio.