Table 1.

House dust mite allergens.

Groups	Biochemical function	MW^a (SDS-PAGE, kDa)	Species^b	IgE binding^c (%)
1	Cysteine protease	24, 25, 27, 39	Bt, Df, Dp, Dm, Em	33–87
2	NPC2 family	15	Bt, Df, Dp, Em, Gy, Ld, Tp	46–75
3	Trypsin	29	Bt, Df, Dp, Em, Ah, Tp	16–97
4	Alpha-amylase	57.9	Bt, Df, Dp, Em,	10–46
5	Unknown	14	Bt, Dp, Ld	20
6	Chymotrypsin	25	Bt, Df, Dp	8–41
7	Unknown	14, 23, 26, 30, 31	Dp, Df, Ld	37–53
8	Glutathione S-transferase	27, 32,	Bt, Df, Dp	25–41
9	Collagenolytic serine protease	29	Dp, Gd, Ld	92
10	Tropomyosin	33, 36, 37, 42	Bt, Ca, Df, Dp, Ld, Tp	5.6–80.6
11	Paramyosin	98, 103, 110	Bt, Df, Dp	41.7–75
12	Unknown	14	Bt	50
13	Fatty acid-binding protein	15	Bt, As, Df, Ld, Tp	23
14	Apolipophorin	177	Df, Dp, Em, Ld	65.8–84.2
15	Chitinase	98/109	Df	41
16	Gelsolin/villin	53	Df, Dp, Em,	47
17	Calcium binding protein	53	Df	53
18	Chitin-binding protein	60	Df	54
19	Anti-microbial peptide homologue	7	Bt	10
20	Arginine kinase	40	Df, Dp	50
21		13/14	Bt, Df, Dp	50
22		13	Df, Dp	/
23	Peritrophin-like protein domain (PF01607)	14	Dp	74
24	Ubiquinol–cytochrome c reductase binding protein homologue	13	Df, Dp	29.4
25	Triosephosphate isomerase	34	Df	34.6
26	Myosin alkali light chain	18	Df	68.2
27	Serpin	48	Df	85.3
28	Heat shock protein	70	Df, Tp	70%
29	Peptidyl-prolyl cis-trans isomerase (cyclophilin)	16	Df	85.36
30	Ferritin	16	Df	63.41
31	Cofilin	15	Df	25
32	Secreted inorganic pyrophosphatase	35	Df	68.4
33	Alpha-tubulin	52	Df	25
34	Enamine/imine deaminase	16	Df, Tp	68.42
35	Chitinase-like protein	14.4	Df, Tp	51.43
36	Peritrophin-like protein domain	23	Df, Dp, Tp	50

Data derived from http://www.allergen.org/.

Molecular Weight (MW) calculated from cDNA (sodium dodecylsulphate-polyacrylamide gel electrophoresis [SDS-PAGE] of natural allergen, if different).

Allergen described for the species designated by initials: Blomia tropicalis, Acarus siro, Dermatophagoides pteronyssinus, Dermatophagoides farinae, Chortoglyphus arcuatus, Dermatophagoides microceras, Euroglyphus maynei, Glycyphagus domesticus, Lepidoglyphus destructor, Tyrophagus putrescentiae.

Binding (% patients, variation due to patient selection).