Extended Data Figure 4: Activation of bitter cortical projections to posterior BLA is aversive.

As shown in Figure 1 and Extended Data Fig. 1, a fraction of the bitter cortico-amygdalar projections terminate in posterior BLA (BLAp). As expected, stimulation of these projections elicits aversive responses. a, Representative histograms showing licking events in the presence (blue) or absence (grey) of photostimulation of bitter cortical projections to posterior BLA. AAV-ChR2 was injected into bitter cortex, and the stimulating fiber was targeted above posterior BLA (coordinates: bregma −2 mm; lateral 3.4 mm; ventral 4.3 mm). b, Quantitation of licking responses (n=3 mice, two-tailed paired t-test, P=0.0121). Values are mean ± s.e.m.