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. Author manuscript; available in PMC: 2018 Oct 25.
Published in final edited form as: Conf Proc IEEE Eng Med Biol Soc. 2013;2013:6821–6824. doi: 10.1109/EMBC.2013.6611124

Figure 4.

Figure 4.

Discrimination of microRNAs with single-base difference. The probe P7b was used to target Let-7b and Let-7c. The sequences of the two microRNAs contain a single-base difference (Table 1). The nanopore current was recorded at +130 mV in 3 M/0.5 M cis/trans KCl. a-b. Level 2 signatures produced by the fully-matched complex Let-7b•P7b (a), and Let-7c•P7b (b).