Table 2.
Hazard Ratios for the Risk of Cancer from Cox Regression Modelsa
Outcomeb | N | Unadjusted HR | 95% CI | P-value | Adjusted HRc | 95% CI | P-value | |
---|---|---|---|---|---|---|---|---|
All Patients | Any Cancer | 87996 | 0.70 | 0.63–0.77 | <.001 | 0.67 | 0.60–0.74 | <.001 |
Obesity-Associated Cancer | 87996 | 0.60 | 0.52–0.70 | <.001 | 0.59 | 0.51–0.69 | <.001 | |
Cancer not Associated with Obesity | 87996 | 0.83 | 0.71–0.96 | 0.01 | 0.77 | 0.66–0.89 | 0.001 | |
Women | Any Cancer | 71341 | 0.66 | 0.50–0.75 | <.001 | 0.64 | 0.57–0.72 | <.001 |
Obesity-Associated Cancer | 71341 | 0.58 | 0.50–0.68 | <.001 | 0.58 | 0.49–0.67 | <.001 | |
Cancer not Associated with Obesity | 71341 | 0.80 | 0.67–0.96 | 0.02 | 0.74 | 0.62–0.89 | 0.001 | |
Men | Any Cancer | 16655 | 0.85 | 0.68–1.07 | 0.17 | 0.79 | 0.63–1.002 | 0.054 |
Obesity-Associated Cancer | 16655 | 0.71 | 0.47–1.07 | 0.1 | 0.7 | 0.46–1.07 | 0.1 | |
Cancer not Associated with Obesity | 16655 | 0.94 | 0.71–1.24 | 0.64 | 0.85 | 0.64–1.12 | 0.25 | |
All models accounted for matching on age, sex, BMI, Elixhauser comorbidity index score and study site
all outcomes start at 6 months after the index date
Models adjusted for race, diabetes, hyperlipidemia, hypertension, coronary artery disease, peripheral vascular disease, nonalcoholic steatohepatitis, a history of smoking, alcohol use, and use of hormone replacement therapy.