Table 1.
Examples of Recent Heritability estimates from Genome-wide Complex Trait Analysis
| Outcome | SNP Heritability (SE) | Sample Size | Reference |
|---|---|---|---|
| Socioeconomic Traits/Behaviors | |||
| Education (years) | 0.17 (0.07) | 6,414 | Conley et al., 2014 |
| Education (years) | 0.21 (0.05) | 6,578 | Marioni et al., 2014 |
| Education (years) | 0.33 (0.10) | 4,233 | Boardman et al., 2015 |
| Education (years) | 0.15 (0.02) | 20,450 | Okbay et al., 2016 |
| Educational achievement | 0.31 (0.12) | 3,152 | Krapohl and Plomin, 2016 |
| Reading Achievement Test | 0.43 (0.10) | 3,680 | Robinson et al., 2015 |
| Multiple Deprivation Index | 0.18 (0.05) | 6,533 | Marioni et al., 2014 |
| Family Socioeconomic Status | 0.20 (0.11) | 3,152 | Krapohl and Plomin, 2016 |
| Socioeconomic Status (Age 2) | 0.18 (0.12) | 3,000 | Trzaskowski et al., 2014 |
| Socioeconomic Status (Age 7) | 0.19 (0.12) | 3,000 | Trzaskowski et al., 2014 |
| Health Behaviors/Traits | |||
| Moderate to Vigorous Activity | 0.17 (0.09) | 4,244 | Richmond et al., 2014 |
| Sedentary Time | 0.25 (0.09) | 4,244 | Richmond et al., 2014 |
| Total Physical Activity | 0.21 (0.10) | 4,244 | Richmond et al., 2014 |
| Drug Use | 0.22 (0.16) | 3,452 | Vrieze et al., 2013 |
| Drug Dependence | 0.36 (0.13) | 2,596 | Palmer et al., 2015 |
| Dependence Vulnerability | 0.33 (0.13) | 2,596 | Palmer et al., 2015 |
| Problematic Drug Use | 0.25 (0.13) | 2,596 | Palmer et al., 2015 |
| Alcohol Consumption | 0.16 (0.16) | 3,452 | Vrieze et al., 2013 |
| Alcohol Dependence | 0.12 (0.16) | 3,452 | Vrieze et al., 2013 |
| Nicotine Use/Dependence | 0.18 (0.16) | 3,452 | Vrieze et al., 2013 |
| Psychological Traits/Behaviors | |||
| Subjective Well-Being | 0.05–0.10 (0.05–0.10) | 11,500 | Rietveld et al., 2013 |
| Reporting Stressful Life Events | 0.30 (0.15) | 2,578 | Power et al., 2013 |
| Bipolar Disorder | 0.37 (0.04) | 2,599 | Lee et al., 2011 |
| Bipolar Disorder | 0.59 (0.06) | 2,000 | Speed et al., 2012 |
| ADHD | 0.42 (0.13) | 1,040 | Yang et al., 2013 |
| ADHD Combined Scale (Parent report) | 0.22–0.40 (0.14) | 5,928 | Pappa et al., 2015 |
| ADHD Inattentive Scale (Parent report) | 0.24–0.37 (0.14) | 5,928 | Pappa et al., 2015 |
| Hyperactive-Impulsive (Parent report) | 0.33–0.45 (0.14–0.15) | 5,928 | Pappa et al., 2015 |
| Externalizing Scale (Teacher report) | 0.44–0.46 (0.22–0.23) | 5,928 | Pappa et al., 2015 |
| Attention Problems (Teacher report) | 0.49–0.71 (0.22) | 5,928 | Pappa et al., 2015 |
| Adult Antisocial Behavior | 0.55 (0.41) | 2,172 | Tielbeek et al., 2012 |
| Depression | 0.19 (0.10) | 4,233 | Boardman et al., 2015 |
| Major Depressive Disorder | 0.32 (0.09) | 4,605 | Lubke et al., 2012 |
| Behavioral Disinhibition | 0.19 (0.16) | 3,452 | Vrieze et al., 2013 |
| Neuroticism | 0.06 (0.03) | 12,000 | Vinkhuyzen et al., 2012 |
| Neuroticism | 0.15 (0.08) | 4,855 | Power and Pluess, 2015 |
| Borderline Personality Features | 0.23 (0.09) | 7, 125 | Lubke et al., 2014 |
| Callous-Emotional Behavior | 0.07 (0.12) | 2,930 | Viding et al., 2013 |
| Extraversion | 0.12 (0.03) | 12,000 | Vinkhuyzen et al., 2012 |
| Anxiety Related Behaviors | 0.01–0.12 (0.12) | 2,810 | Viding et al., 2013 |
| Openness | 0.21 (0.08) | 4,855 | Power and Pluess, 2015 |
| Schizophrenia | 0.39 (0.12) | 1,097 | Goes et al., 2015 |
| Loneliness | 0.27–0.16 (0.12–0.06) | 7,556 | Gao et al., 2016 |
| Aggressive Behavior (Age 4) | 0.10 (0.06) | 5,505 | Pappa et al., 2016 |
| Aggressive Behavior (Early Adolescence) | 0.12 (0.06) | 5,299 | Pappa et al., 2016 |
| Physiological Traits/Behaviors | |||
| Self-Rated Health | 0.18 (0.10) | 4,233 | Boardman et al., 2015 |
| Self-Rated Health | 0.13 (0.01) | 112,151 | Harris et al., 2017 |
| BMI | 0.31 (0.07) | 6,320 | Conley et al., 2014 |
| BMI | 0.43 (0.10) | 4,233 | Boardman et al., 2015 |
| Type 1 Diabetes | 0.28 (0.04) | 2,599 | Lee et al., 2011 |
| Type 1 Diabetes | 0.73 (0.06) | 2,000 | Speed et al., 2012 |
| Type 2 Diabetes | 0.35 (0.06) | 2,000 | Speed et al., 2012 |
| Coronary Artery Disease | 0.39 (0.06) | 2,000 | Speed et al., 2012 |
| Cholesterol High Density Lipoprotien | 0.45 (0.02) | 19,977 | Zaitlen et al., 2013 |
| Cholesterol Low Density Lipoprotien | 0.20 (0.06) | 4,547 | Zaitlen et al., 2013 |
| Hypertension | 0.42 (0.06) | 2,000 | Speed et al., 2012 |
| Age at Menarche | 0.44 (0.02) | 15,150 | Zaitlen et al., 2013 |
| Age at Menopause | 0.40 (0.05) | 5,540 | Zaitlen et al., 2013 |
| Total children | 0.10 (0.02) | 15,000 | Zaitlen et al., 2013 |
| Rheumatoid Arthritis | 0.57 (0.06) | 2,000 | Speed et al., 2012 |
| Crohn’s Disease | 0.61 (0.08) | 2,599 | Lee et al., 2011 |
| Crohn’s Disease | 0.54 (0.06) | 2,000 | Speed et al., 2012 |
| Pediatric Obesity | 0.37 (0.15) | 3,152 | Llewellyn et al., 2013 |
| Parkinson’s Disease | 0.27 (0.05) | 7,096 | Keller et al., 2012 |
| Parkinson’s Disease | 0.22 (0.02) | 3,426 | Do et al., 2011 |
| Cognitive Traits/Behaviors | |||
| General Cognitive Ability | 0.35 (0.12) | 3,154 | Plomin et al., 2013 |
| General Cognitive Ability | 0.29 (0.05) | 6,609 | Marioni et al., 2014 |
| Nonverbal Cognitive Ability | 0.20 (0.11) | 3,154 | Plomin et al., 2013 |
| Nonverbal Reasoning | 0.41 (0.10) | 3,657 | Robinson et al., 2015 |
| Verbal Cognitive Ability | 0.26 (0.11) | 3,154 | Plomin et al., 2013 |
| Verbal Memory | 0.24 (0.10) | 3,638 | Robinson et al., 2015 |
| Language Ability | 0.29 (0.12) | 3,154 | Plomin et al., 2013 |
| Language Reasoning | 0.30 (0.10) | 3,651 | Robinson et al., 2015 |
| Spatial Reasoning | 0.36 (0.10) | 3,581 | Robinson et al., 2015 |
| Intelligence (Age 7–12) | 0.60 (0.26) | 2,875 | Trzaskowski et al., 2014a |
| Intelligence | 0.51 (0.02) | 3,511 | Davies et al., 2011 |
| Intelligence from Childhood to Old Age | 0.24 (0.20) | 1,940 | Deary et al., 2012 |
| IQ (Age 12) | 0.32 (0.14) | 3,000 | Trzaskowski et al., 2014b |
| IQ (Age 7) | 0.28 (0.17) | 3,000 | Trzaskowski et al., 2014b |
Source: Updated and modified from Domingue et al. (2016)