Table 5.
FAC-MS Results for Library a Screened on GPR17-IAM and Mutated GPR17-IAM Columnsa
| compd | GPR17-IAM-II | Mutated GPR17-IAM |
(tm/tw×100)-100b(%) |
|---|---|---|---|
| UDP | 2.69 | 2.15 | −20.1 |
| 13 | 2.79 | 2.51 | −10.0 |
| 14 | 2.97 | 2.90 | −2.4 |
| 9 | 3.03 | 2.96 | −2.3 |
| 12 | 3.55 | 3.54 | −0.3 |
| MRS 2179 | 3.62 | 3.47 | −4.1 |
| 5 | 3.69 | 4.08 | +10.6 |
| 11 | 4.26 | 4.68 | +10.1 |
| 7 | 4.50 | 5.27 | +17.1 |
| 8 | 4.77 | 5.79 | +21.4 |
| 6 | 5.67 | 7.08 | +24.9 |
| 10 | 6.45 | 8.42 | +30.5 |
| cangrelor | 10.60 | 13.16 | +24.1 |
| 4 | 13.07 | 16.07 | +23.0 |
a
The breakthrough times are the result of a single ranking experiment carried out on the freshly prepared column. Columns: GPR17-IAM-II and mutated GPR17-IAM (19.5 million cells).
b
The breakthrough time variation % was calculated on mutated GPR17-IAM (tw) with respect to GPR17-IAM-II column (tw).