Table 1.
Distribution of four competing treatment status in 90 days of the new start of an antipsychotic medication in the VA patients older than 65 years and with dementia after black box warning, from May 2005 to September 2008, by the three most commonly prescribed antipsychotics
| Olanzapine N = 1424 | Quetiapine N = 7520 | Risperidone N = 5847 | Total N = 14791 | |
|---|---|---|---|---|
| Treatment status in 90 days, N (%) | ||||
| Changeda index medication | 104 (7.3) | 432 (5.7) | 378 (6.5) | 914 (6.2) |
| Continued treatment ≥90 days | 506 (35.5) | 2787 (37.1) | 2026 (34.7) | 5319 (36.0) |
| Stoppedb index medication | 762 (53.5) | 4078 (54.2) | 3229 (55.2) | 8069 (54.6) |
| Died during index medication | 52 (3.7) | 223 (3.0) | 214 (3.7) | 489 (3.3) |
| Days to treatment status changec | 52 (60) | 54 (60) | 52 (60) | 52 (60) |
| Daily dose in mg/day | ||||
| Initial dose | 5.0 (2.5, 5.3) | 25.0 (25.0, 56.3) | 0.5 (0.5, 0.8) | |
| Last dose | 5.0 (2.5, 5.6) | 50.0 (50.0, 62.8) | 0.5 (0.5, 0.9) | |
| Daily haloperidol equivalent dose | ||||
| Initial prescribed dose | 2.0 (1.1, 2.2) | 0.2 (0.3, 0.7) | 0.6 (0.7, 1.0) | |
| Last dose | 2.0 (1.1, 2.4) | 0.5 (0.6, 0.8) | 0.6 (0.7, 1.2) | |
Cell values are median (interquartile range) for days to treatment status change and median (interquartile range, mean) for daily doses, unless otherwise specified.
a
Includes 35 (3.8%) deaths after changing treatment but within 90 days.
b
Includes 373 (4.6%) deaths after stopping treatment but within 90 days.
c
Treatment change is defined as change or stop in the index medication treatment, death, or 90 days, whichever is earlier.