Table A2.
Patient and facility characteristics at the time of the newly filled antipsychotic medication by 90 days treatment status
| Treatment statusa | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Changed 914 (6.2) |
Continued 5319 (36.0) |
Stopped 8069 (54.6) |
Died 489 (3.3) |
Total 14,791 |
||||||||||||
| Characteristics | N | % | N | % | N | % | N | % | N | % | ||||||
| Age on index fill date‡ | 80.5 | ±6.1 | 80.6 | ±5.9 | 80.6 | ±6.1 | 82.5 | ±5.8 | 80.6 | ±6.1 | ||||||
| Male | 890 | (97.4) | 5195 | (97.7) | 7874 | (97.6) | 486 | (99.4) | 14,445 | (97.7) | ||||||
| Race‡ | ||||||||||||||||
| white | 706 | (77.2) | 4111 | (77.3) | 6051 | (75.0) | 377 | (77.1) | 11,245 | (76.0) | ||||||
| Black | 85 | (9.3) | 352 | (6.6) | 999 | (12.4) | 28 | (5.7) | 1464 | (9.9) | ||||||
| Other | 17 | (1.9) | 86 | (1.6) | 128 | (1.6) | 4 | (0.8) | 235 | (1.6) | ||||||
| Unknown | 106 | (11.6) | 770 | (14.5) | 891 | (11.0) | 80 | (16.4) | 1847 | (12.5) | ||||||
| Hispanic‡ | 85 | (11.0) | 234 | (5.4) | 661 | (9.9) | 14 | (4.0) | 994 | (8.2) | ||||||
| Married‡ | 582 | (63.7) | 3534 | (66.4) | 4981 | (61.7) | 291 | (59.5) | 9388 | (63.5) | ||||||
| Dementia types | ||||||||||||||||
| Alzheimer’s‡ | 799 | (87.4) | 4635 | (87.1) | 6865 | (85.1) | 425 | (86.9) | 12,724 | (86.0) | ||||||
| Vascular dementia‡ | 198 | (21.7) | 1099 | (20.7) | 2011 | (24.9) | 112 | (22.9) | 3420 | (23.1) | ||||||
| DLBD/PDD | 37 | (4.1) | 284 | (5.3) | 437 | (5.4) | 29 | (5.9) | 787 | (5.3) | ||||||
| Other dementia | 39 | (4.3) | 223 | (4.2) | 341 | (4.2) | 10 | (2.0) | 613 | (4.1) | ||||||
| Prior medication use | ||||||||||||||||
| Benzodiazapine | 219 | (24.0) | 1257 | (23.6) | 1921 | (23.8) | 135 | (27.6) | 3532 | (23.9) | ||||||
| Valproic acids | 61 | (6.7) | 337 | (6.3) | 527 | (6.5) | 27 | (5.5) | 952 | (6.4) | ||||||
| Antidepressant‡ | 451 | (49.3) | 3071 | (57.7) | 4486 | (55.6) | 249 | (50.9) | 8257 | (55.8) | ||||||
| Carbamazepine | 13 | (1.4) | 66 | (1.2) | 85 | (1.1) | 7 | (1.4) | 171 | (1.2) | ||||||
| Other anticonvulsant | 94 | (10.3) | 581 | (10.9) | 920 | (11.4) | 48 | (9.8) | 1643 | (11.1) | ||||||
| Opioid | 311 | (34.0) | 1694 | (31.9) | 2709 | (33.6) | 194 | (39.7) | 4908 | (33.2) | ||||||
| Clinical diagnoses | ||||||||||||||||
| Alcohol abuse/dependence‡ | 30 | (3.3) | 126 | (2.4) | 288 | (3.6) | 8 | (1.6) | 452 | (3.1) | ||||||
| Drug abuse/dependence | 30 | (3.3) | 140 | (2.6) | 237 | (2.9) | 12 | (2.5) | 419 | (2.8) | ||||||
| PTSD | 58 | (6.4) | 292 | (5.5) | 505 | (6.3) | 13 | (2.7) | 868 | (5.9) | ||||||
| Other anxiety disorder‡ | 107 | (11.7) | 482 | (9.1) | 817 | (10.1) | 53 | (10.8) | 1459 | (9.9) | ||||||
| Personality disorders | 5 | (0.6) | 35 | (0.7) | 62 | (0.8) | 1 | (0.2) | 103 | (0.7) | ||||||
| Delirium‡ | 465 | (50.9) | 2391 | (45.0) | 4123 | (51.1) | 248 | (50.7) | 7227 | (48.9) | ||||||
| Depression‡ | 299 | (32.7) | 1655 | (31.1) | 2591 | (32.1) | 116 | (23.7) | 4661 | (31.5) | ||||||
| Schizophrenia/affective‡ | 15 | (1.6) | 87 | (1.6) | 204 | (2.5) | 8 | (1.6) | 314 | (2.1) | ||||||
| Other psychoses‡ | 176 | (19.3) | 977 | (18.4) | 1675 | (20.8) | 89 | (18.2) | 2917 | (19.7) | ||||||
| Parkinson’s diseaseb,‡ | 74 | (8.1) | 520 | (9.8) | 858 | (10.6) | 60 | (12.3) | 1512 | (10.2) | ||||||
| Bipolar 1b | 27 | (3.0) | 110 | (2.1) | 180 | (2.2) | 4 | (0.8) | 321 | (2.2) | ||||||
| Bipolar 2b,† | 6 | (0.7) | 57 | (1.1) | 112 | (1.4) | 2 | (0.4) | 177 | (1.2) | ||||||
| Number of comorbiditiesc,‡ | 1.5 | ±1.8 | 1.4 | ±1.7 | 1.6 | ±1.9 | 2.2 | ±2.3 | 1.5 | ±1.8 | ||||||
| Prior treatment | ||||||||||||||||
| ≥1 psych visit in 30 days‡ | 381 | (41.7) | 1873 | (35.2) | 3268 | (40.5) | 94 | (19.2) | 5616 | (38.0) | ||||||
| No. any inpatient days‡ | 3.5 | ±15.3 | 3.7 | ±18.6 | 5.3 | ±20.0 | 6.6 | ±14.7 | 4.7 | ±19.1 | ||||||
| No. nursing home days‡ | 1.2 | ±10.1 | 1.8 | ±16.7 | 2.8 | ±20.3 | 3.2 | ±22.9 | 2.4 | ±18.7 | ||||||
| Years since dementia diagnosis‡ | 1.8 | ±2.2 | 1.9 | ±2.1 | 2.1 | ±2.2 | 1.9 | ±2.1 | 2.0 | ±2.2 | ||||||
| Fiscal year of medication start | ||||||||||||||||
| 2005 | 185 | (20.2) | 1137 | (21.4) | 1673 | (20.7) | 111 | (22.7) | 3106 | (21.0) | ||||||
| 2006 | 271 | (29.7) | 1723 | (32.4) | 2503 | (31.0) | 144 | (29.5) | 4641 | (31.4) | ||||||
| 2007 | 245 | (26.8) | 1463 | (27.5) | 2228 | (27.6) | 142 | (29.0) | 4078 | (27.6) | ||||||
| 2008 | 213 | (23.3) | 996 | (18.7) | 1665 | (20.6) | 92 | (18.8) | 2966 | (20.1) | ||||||
| Facility characteristics | ||||||||||||||||
| Urban facility‡ | 834 | (91.3) | 4640 | (87.2) | 7301 | (90.5) | 432 | (88.3) | 13,207 | (89.3) | ||||||
| High academic affiliation | 454 | (49.7) | 2610 | (49.1) | 3862 | (47.9) | 233 | (47.7) | 7159 | (48.4) | ||||||
| Number of beds‡ | 423 | ±275 | 432 | ±283 | 416 | ±266 | 394 | ±262 | 421 | ±273 | ||||||
| Region‡ | ||||||||||||||||
| Northeast | 172 | (18.8) | 1078 | (20.3) | 1582 | (19.6) | 80 | (16.4) | 2912 | (19.7) | ||||||
| Midwest | 181 | (19.8) | 1408 | (26.5) | 1675 | (20.8) | 120 | (24.5) | 3384 | (22.9) | ||||||
| West | 157 | (17.2) | 885 | (16.6) | 1206 | (15.0) | 87 | (17.8) | 2335 | (15.8) | ||||||
| South | 404 | (44.2) | 1948 | (36.6) | 3606 | (44.7) | 202 | (41.3) | 6160 | (41.7) | ||||||
Unless otherwise stated, all variables are defined based on data during 1 year prior to the index medication fill date.
Abbreviations: PTSD, post-traumatic stress disorder; DLBD, diffuse Lewy body disease; PDD, Parkinson’s disease dementia.
b
Parkinson’s disease includes ICD 9 of 3320, 3330, and 33390; bipolar 1 includes ICD 9 of 2960, 2961, 2964, 2965, 2966, and 2967; bipolar 2 includes ICD 9 of 2968.
c
Weighted Charlson diagnoses score, excluding dementia.
†
p < 0.05.
‡
p < 0.01 for comparison across the four 90 days treatment status groups.