Figure 1.

16p11.2 del/+ mice are hyperactive throughout the diurnal cycle. (A and B) Infrared beam breaks in the XY (horizontal) and Z (vertical) (B) axis plotted for all four groups, in 1 hour bins, across the 24-hr day. Gray box indicates the dark (active) period. (C and D) 16p11.2 del/+ mice have significantly greater activity relative to wildtype littermates, irrespective of sex, in both the horizontal (C) and vertical (D) axes. (E and F) There are no significant differences between 16p11.2 del/+ and wildtype mice in elevated zero-maze time spent in open arms (E) or risk assessment (F). (G and H) There are no differences in open field total ambulation (G) or time spent in center (H) between 16p11.2 del/+ mice and wildtype controls. Mean 6 standard error of the mean (s.e.m.) * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.