Table 2.
Prenatal determinants of Brain Derived Neurotrophic Factor (BDNF) in neonates.
| Neonatal BDNF |
||
|---|---|---|
| Univariate model | Multivariable model | |
| B (95%CI) | B (95%CI) | |
| Maternal age | −0.001 (−0.003, 0.002) | - |
| Nulliparous, yes | −0.05 (−0.07, −0.02)** | −0.04 (−0.07, −0.02)** |
| Race/ethnicity | ||
| Non-Hispanic White | Reference | Reference |
| Not White or Other | −0.05 (−0.09, −0.02)** | −0.05 (−0.09, −0.02)** |
| Educational levels | ||
| Less than high school | −0.04 (−0.10, 0.02) | 0.004 (−0.07, 0.06) |
| High school equivalent | 0.01 (−0.03, 0.06) | 0.03 (−0.01, 0.08) |
| Some college | −0.05 (−0.08, −0.01)** | −0.03 (−0.07, 0.003)* |
| College graduate | −0.02 (−0.05, 0.02) | −0.02 (−0.06, 0.02) |
| Graduate/professional school | Reference | Reference |
| Having private health insurance | 0.02 (−0.01, 0.05) | - |
| Smoking in pregnancy, yes | −0.04 (−0.08, −0.003)** | −0.05 (−0.08, −0.01)** |
| Alcohol consumption during pregnancy, yes | −0.03 (−0.07, 0.004)* | −0.04 (−0.08, −0.003)** |
| Diagnosis of depressive disorders in pregnancy, yes | 0.06 (−0.01, 0.13)* | 0.07 (−0.01, 0.14) |
| Infertility treatment, yes | 0.04 (−0.01, 0.09) | - |
| Fish oil supplement during pregnancy | −0.02 (−0.06, 0.02) | - |
| Multivitamin supplement during pregnancy | 0.01 (−0.02, 0.03) | - |
| Pre-pregnancy body mass index | ||
| Thin or normal weight (<25 kg/m2) | Reference | Reference |
| Overweight (25–29.99 kg/m2) | −0.02 (−0.06, 0.01) | −0.03 (−0.06, 0.01) |
| Obese (>30 kg/m2) | −0.07 (−0.10, −0.04)** | −0.07 (−0.10, −0.04)** |
| Preterm delivery | −0.07 (−0.12, −0.02)** | −0.06 (−0.12, −0.01)** |
| Plurality | −0.08 (−0.16, 0.01)* | −0.04 (−0.13, 0.05) |
Analyses were performed in the primary cohort including singletons and one randomly selected twin of each pair (n=2637). First, maternal age, maternal race, maternal educational levels, parity, infertility treatment, having private insurance, maternal categories of BMI, maternal history of drinking and smoking in pregnancy and maternal history of depressive disorders in pregnancy were included in the model of association with BDNF separately (Univariate model). Next, a parsimonious model including factors that were statistically significant (p<0.1) from these analyses was built to estimate the association of determinants with neonatal BDNF (Multivariable model).
BDNF had a skewed distribution and therefore was log-transformed. Units for BDNF levels are log ng/ml.
denotes P values <0.1
denotes P values <0.05