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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: J Immunol. 2018 Oct 1;201(7):1827–1834. doi: 10.4049/jimmunol.1800556

Figure 2. Non-redundant actions of iNKT and γδ T cells promote adipose tissue homeostasis.

Figure 2.

(Top) Adipose iNKT cells expands Tregs via production of IL-2 and M2 macrophages via production of IL-10. Furthermore, activation of adipose iNKT cells induces weight loss and thermogenesis through an FGF21-dependent mechanism. (Bottom) IL-17A-producing γδ T cells in adipose tissue drive Treg expansion by inducing stromal cells to produce IL-33. Additionally, a γδ – IL-17A axis in adipose tissue is critical for maintenance of body temperature at thermoneutrality and upon cold challenge.