Figure 6.

H1/AIM2 inhibits the proliferation, migration and invasion of renal cancer cells through enhanced the inflammasome activation. 786‐O and AOSRC‐2 cells in 35‐mm dish were treated by 4 μg H1/pAIM2 or control with or without Ac‐YVAD‐MCA (50 μmol/L). (A). Forty‐eight hours after treatment, the levels of caspase‐1 were measured in 786‐O and OSRC‐2. (B). ELISA analysis of IL‐1β in renal cancer cells. (C and D). CCK‐8 cell proliferation assay was performed in renal cancer cells. (E and F). The migration was detected in renal cancer cells. (G and H). The invasion was detected in renal cancer cells. Data are from one representative experiment of three performed and presented as the mean ± SD. The different significance was set at **P < 0.01, and ***P < 0.001