Figure 4.

MYB was a downstream target of miR‐298. A, The binding sites of miR‐298 on MYB. B, The luciferase assay showed that cells transfected with miR‐298 had less luciferase activity than those transfected with miR‐ctrl. C, miR‐298 repressed MYB mRNA expression in hepatocellular carcinoma (HCC) cells. D, miR‐298 repressed MYB protein expression in HCC cells. E, Anti‐miR‐298 treatment led to the restoration of MYB in sh‐LINC01287 cells. F, The MTT assay revealed that sh‐LINC01287 cells grew more slowly than the sh‐ctrl cells, while overexpression of MYB rescued the effect. G, The colony formation assay showed that sh‐LINC01287 cells formed smaller and fewer colonies than the sh‐ctrl cells, which was counteracted by overexpression of MYB. H, LINC01287 down‐regulation affected the cell cycle distribution, which was counteracted by overexpression of MYB. I, LINC01287 down‐regulation inhibited HCC cell invasion ability, which was rescued by overexpression of MYB