Figure 1.

The expression of ATP1B1 was down‐regulated in aged RPE and wet AMD. A, We analysed the data set on the GEO (gene expression omnibus, NCBI). The expression of ATP1B1 was reduced significantly in aged mice (4 vs 26 months, P < 0.01). B, the expression of ATP1B1 and ATP1A1 in normal and AMD retina were analysed. ATP1B1 expression in normal macula (n = 28) was three times higher than from extramacular areas (n = 27, P < 0.01). ATP1B1 expression in both macula with CNV (Choroidal Neovascularization) and with GA (geographic atrophy) (n = 9) was reduced significantly compared to that in normal macula (n = 28, P < 0.05). C, Expression of ATP1A1 was not different between macula and extramacular or normal and AMD. **P < 0.01, *P < 0.05