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. 2018 Sep 11;22(11):5539–5551. doi: 10.1111/jcmm.13828

Figure 7.

Figure 7

Effects of IL‐17A and STK treatments on human NP cells under hypoxia. A, B, IL‐6 mRNA expression in human NP cells treated with or without 50 ng/mL of IL‐17A and 50‐100 μg/mL STK for 24 hours (A) and 48 hours (B). Treatment with 100 μg/mL STK significantly suppressed expression of IL‐6 mRNA at both 24 and 48 hours. Results shown as mean ± SD; n = 4, *P < 0.05. C, D, COX‐2 mRNA expression in human NP cells treated with or without 50 ng/mL of IL‐17A and 50‐100 μg/mL STK for 24 hours (C) and 48 hours (D). Treatment with 50 μg/mL STK significantly suppressed expression of COX‐2 mRNA at 48 hours (D). Results shown as mean ± SD; n = 4, *P < 0.05. E, Quantification of colonies formed in NP cells treated with 0‐100 ng/mL IL‐17A after 10 days of culture in methylcellulose‐based medium. F, Quantification of colonies formed in NP cells treated with 50 ng/mL IL‐17Aand 0‐200 μg STK after 10 days of culture in methylcellulose‐based medium. Results shown as mean ± SD; n = 3, *P < 0.05