Table 1.
Demographic | Pre‐eclamptic with AGA baby (n = 9) | Pre‐eclamptic with SGA baby (n = 9) | PTL controls (n = 9) | Term controls (n = 9) |
---|---|---|---|---|
Age (years) | ||||
Mean | 31.13 | 32.52 | 29.86 | 32.88 |
Range | 19‐43 | 20‐42 | 17‐40 | 29‐39 |
Parity | ||||
Nullipara | 7 | 4 | 6 | 2a |
Multipara | 2 | 5 | 3 | 7a |
Gestational age at delivery (weeks) | ||||
Mean | 30.4 | 30.3 | 29.55 | 38.6a |
Range | 26.6‐33.2 | 27.0‐33.0 | 26.0‐32.6 | 37.4‐40.1 |
Indication(s) for delivery | ||||
Severe pre‐eclampsia | 9 | 9 | 0 | 0 |
Non‐reassuring foetal testing | 3 | 9 | 2 | 0 |
Spontaneous preterm labour | 0 | 0 | 9 | 0 |
Induction of labour | 4 | 3 | 0 | 0 |
Caesarean Delivery | 9 | 9 | 4 | 9 |
Max sBP | 158.8 ± 18.44a | 165.2 ± 15.88a | 122.5 ± 17.89 | 116.6 ± 11.93 |
Max dBP | 100.7 ± 7.34a | 107.8 ± 8.91a | 69.9 ± 11.86 | 71 ± 7.65 |
Proteinuria (dip stick) | 3‐4 | 1‐4 | n/a | n/a |
AST (μ/L) | 14‐126a | 18‐158a | 10‐22 | n/a |
ALT (μ/L) | 7‐98a | 15‐129a | 10‐20 | n/a |
Creatinine (μmol/L) | 50‐102a | 50‐80a | 36‐39 | n/a |
Pre‐pregnancy BMI | 28.89 ± 4.05 | 28.58 ± 5.37 | 24.10 ± 4.26 | 26.36 ± 6.64 |
Celestone treatment | 6 | 9 | 9 | 0a |
Umbilical artery Doppler | ||||
AEDF | 3 | 7a | n/a | n/a |
REDF | 5 | 2 | n/a | n/a |
Birthweight (g) | 1284.11 ± 304.7 | 930.0 ± 134.16 | 1452.54 ± 476.32 | 3316.25 ± 365.70 |
Birthweight percentile | ||||
<10th | 0 | 3a | 0 | 0 |
<5th | 0 | 6a | 0 | 0 |
Gender | ||||
Male | 3 | 4 | 8 | 5 |
Female | 6 | 5 | 1 | 4 |
Placental weight (g) | 321.0 ± 78.28. | 232.67 ± 98.92 | 362.5 ± 69.07 | 598.75 ± 107.32a |
All clinical data were collected from the patient records by the Placental Biobank of Mount Sinai Hospital, Toronto, with ethical approval from the Mount Sinai Research Ethics Board and written patient consent. Statistical differences between the groups were tested by ANOVA analysis or by Student's t test where appropriate.
AEDF, absent end‐diastolic flow; AGA, average weight for gestational age; AST, aspartate transaminase; ALT, alanine aminotransferase; dBP, diastolic blood pressure; SGA, small weight for gestational age; sBP, systolic blood pressure; REDF, reduced end‐diastolic flow.
P < 0.05.