Figure 6.

IBC down‐regulated CD44 expression mediated by the ERα pathway and inhibited tumour growth in MCF‐7/R xenograft models. A, MCF‐7/R cells were subcutaneously injected into the right flank of nude mice (6 mice per group) on day 0. When the tumour volume reached 50 mm³, the mice were intraperitoneally administered with IBC (100 mg/kg) daily for 24 d. Tumour volume was measured at the indicated time‐points. B, Representative immunohistochemistry images of ERα and CD44 staining in tumour tissues of nude mice. C, Quantitative image analysis utilized IPP software on immunohistochemical staining described in Figure 6B of ERα and CD44 protein expression. *P < .05, **P < .01