Table 2.
Life's Simple 7 in Relation to White Matter Hyperintensity Volume and Cerebral Volume (N=1031)
| White Matter Hyperintensity Volume Beta (95% Confidence Interval), P Valuea | Cerebral Volume/Intracranial Volume Beta (95% Confidence Interval), P Valuea | |
|---|---|---|
| Ideal CVH score (continuous, range 0–14) | −0.029 (−0.055, −0.002), 0.03 | 0.144 (0.039, 0.249), 0.01 |
| No. of ideal CVH factors achieved (continuous per factor) | −0.047 (−0.093, −0.002), 0.04 | 0.300 (0.114, 0.485), 0.002 |
| No. of ideal CVH factors | P=0.15 | P=0.06 |
| 0 to 1 | Ref | Ref |
| 2 | −0.079 (−0.228, 0.069), 0.30 | 0.595 (−0.003, 1.193), 0.05 |
| 3 | −0.168 (−0.319, −0.016), 0.03 | 1.106 (0.496, 1.715), 0.0004 |
| 4 to 7 | −0.135 (−0.305, 0.036), 0.12 | 0.902 (0.215, 1.589), 0.01 |
| Ideal CVH components | ||
| Blood pressure ideal | 0.028 (−0.180, 0.235), 0.79 | −0.099 (−0.949, 0.751), 0.82 |
| BMI ideal | −0.028 (−0.147, 0.091), 0.64 | 0.319 (−0.169, 0.806), 0.20 |
| Total cholesterol ideal | −0.041 (−0.148, 0.067), 0.46 | 0.070 (−0.371, 0.512). 0.75 |
| Smoking ideal | −0.203 (−0.333, −0.073), 0.002 | 0.778 (0.245, 1.310), 0.004 |
| Physical activity ideal | 0.014 (−0.101, 0.129), 0.81 | −0.038 (−0.510, 0.434), 0.87 |
| Blood glucose ideal | −0.044 (−0.154, 0.067), 0.44 | 0.673 (0.221, 1.124), 0.004 |
| Diet ideal | −0.554 (−1.714, 0.605), 0.35 | −1.520 (−6.271, 3.231), 0.53 |
BMI indicates body mass index; CVH, cardiovascular health.
a
Adjusted for time from baseline to magnetic resonance imaging, age at magnetic resonance imaging, sex, race/ethnicity, education, and insurance status. Individual components were included in a mutually adjusted model.