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. 2018 Aug 24;7(17):e009384. doi: 10.1161/JAHA.118.009384

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Circulating CD74 and MIF concentrations in healthy, CHD, and HF patients. Using an ELISA technique, we analyzed (A) MIF and (B) sCD74 concentrations in plasma samples of healthy volunteers (n=4), patients with coronary heart disease (CHD; n=5), and patients with advanced heart failure (HF; n=4). C, Ratio of CD74/MIF was calculated by dividing the molar serum concentration of circulating CD74 (19.4 kDa) by MIF (12.5 kDa). Data were analyzed with a 2‐tailed, unpaired t test without multiple correction and represent mean±SEM. *P<0.05 vs CHD cohort; ^$ P<0.05, ^$$ P<0.01 vs healthy cohort, respectively. MIF indicates macrophage migration inhibitory factor; sCD74, soluble CD74.