Table 2.

Enrichment Analysis of sCD74/MIF‐Regulated Genes

Database	ID	Pathway Description	C	Regulated Genes	R	P Value
KEGG	mmu04060	Cytokine‐cytokine receptor interaction	264	Ccl2 (2.90);	4.0	0.0369
				Ccl7 (2.19);
				Tnfsf18 (1.61)
KEGG	mmu04062	Chemokine signaling pathway	196	Nfkbia (1.5);	5.4	0.0170
				Ccl2 (2.90);
				Ccl7 (2.19)
KEGG	mmu05152	Tuberculosis	178	Mapk11 (2.06);	6.0	0.0131
				Ripk2 (1.52);
				Clec4e (3.82)
KEGG	mmu05164	Influenza A	170	Nfkbia (1.5);	6.2	0.0116
				Mapk11 (2.06);
				Ccl2 (2.90)
KEGG	mmu04722	Neurotrophin signaling pathway	123	Nfkbia (1.5);	8.6	0.0048
				Mapk11 (2.06);
				Ripk2 (1.52)
KEGG	mmu05145	Toxoplasmosis	113	Birc3 (1.87);	9.4	0.0038
				Nfkbia (1.5);
				Mapk11 (2.06)
KEGG	mmu05142	Chagas disease (American trypanosomiasis)	103	Nfkbia (1.5);	10.3	0.0029
				Mapk11 (2.06);
				Ccl2 (2.90)
KEGG	mmu04621	NOD‐like receptor signaling pathway	169	Birc3 (1.87);	10.5	<0.0001
				Nfkbia (1.5);
				Mapk11 (2.06);
				Ripk2 (1.52);
				Ccl2 (2.90)
KEGG	mmu04668	TNF signaling pathway	109	Birc3 (1.87);	13.0	0.0002
				Nfkbia (1.5);
				Mapk11 (2.06);
				Ccl2 (2.90)

Birc3 indicates baculoviral IAP repeat‐containing 3, alternative name, cellular inhibitor of apoptosis 2 (cIAP2); C, Total genes regulated in a certain pathway; Ccl, chemokine (C‐C motif) ligand; Clec4e, C‐type lectin domain family 4, member e; FC, fold change; KEGG, Kyoto Encyclopedia of Genes and Genomes; MAPK11, mitogen‐activated protein kinase 11, alternative name, p38 beta; MIF, macrophage migration inhibitory factor; sCD74, soluble CD74; Nfkbia, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha, alternative name, I‐kappa‐B‐alpha (IκBα); R, enrichment factor; Ripk2, receptor‐interacting serine‐threonine kinase 2; sCD74, soluble CD74 receptor ectodomain; Tnfsf18, tumor necrosis factor (ligand) superfamily, member 18.