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. 2018 Sep 1;7(17):e009627. doi: 10.1161/JAHA.118.009627

Figure 4.

Figure 4

Representative stretch activation responses in wild‐type (WT) and knockout (KO) myocardium before and following Myk461 incubation. Representative force responses following a sudden 2% stretch in muscle length (ML) in isometrically contracting WT (black traces), and KO (red traces) myocardial preparations are shown. A through C, Representative WT traces before and following incubation with 0.5 or 1.0 μmol/L Myk461. D through F, Representative KO traces before and following incubation with 0.5 or 1.0 μmol/L Myk461. Incubation with Myk461 slowed krel only in the KO preparations. On the other hand, incubation with Myk461 slowed kdf in both WT and KO preparations. A, Highlights the important phases of the force transients and various stretch activation parameters that are measured from force responses to a sudden 2% stretch in ML (explained in detail in the Methods section). AU indicates arbitrary units.