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. 2018 Sep 4;7(17):e009890. doi: 10.1161/JAHA.118.009890

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Race/ethnicity‐specific associations of aldosterone with incident diabetes mellitus. The cubic spline regressions estimate the hazard ratio of incident diabetes mellitus, according to concentrations of aldosterone (picograms per milliliter, pg/mL) examined as a continuous variable up to the 99th percentile with 3 knots placed at the 25th, 50th, and 75th percentiles. Splines are adjusted for age, sex, study site, education, current alcohol use, physical activity, estimated glomerular filtration rate, systolic blood pressure, and waist circumference. Below each spline is the histogram of the distribution of aldosterone concentration among participants with detectable aldosterone (n=1548).