Table 4.

The Association of Log‐Aldosterone and Log‐Plasma Renin Activity With Incident Diabetes Mellitus Adjusted for Additional Potential Mediators

Cox Proportional Hazards Model—Hazards Ratio (95% CI) for Incident Diabetes Mellitus
Log‐aldosterone SD
Model 1a n=1548	Model 1	1.44 (1.16, 1.78)
Model 2 (adipokines) n=1542	Model 1+log‐leptin and log‐adiponectin	1.38 (1.12, 1.72)
Model 3 (inflammatory markers) n=1493	Model 1+log‐hsCRP, log‐IL‐6, and log‐TNF‐α	1.38 (1.10, 1.71)
Model 4 (adipokines+inflammatory markers) n=1488	Model 1+log‐leptin, log‐adiponectin, log‐hsCRP, log‐IL‐6, and log‐TNF‐α	1.34 (1.07, 1.66)
Log‐plasma renin activity SD (n=1447)
Model 1a n=1474	Model 1	1.21 (0.98, 1.50)
Model 2 (adipokines) n=1467	Model 1+log‐leptin and log‐adiponectin	1.18 (0.96, 1.45)
Model 3 (inflammatory markers) n=1423	Model 1+log‐hsCRP, log‐IL‐6, and log‐TNF‐α	1.14 (0.92, 1.41)
Model 4 (adipokines+inflammatory markers) n=1417	Model 1+log‐leptin, log‐adiponectin, log‐hsCRP, log‐IL‐6, and log‐TNF‐α	1.12 (0.91, 1.38)

hsCRP indicates high‐sensitivity C‐reactive protein; IL‐6, interleukin 6; TNF‐α, tumor necrosis factor‐α.

^aModel 1 adjustments: age, education, sex, study site, race, alcohol, physical activity, estimated glomerular filtration rate, systolic blood pressure, waist circumference (cm), angiotensin‐converting enzyme inhibitors, and angiotensin receptor blockers.