Table 2.

Risk Association Between Plasma Cystathionine and Stroke

Plasma Cystathionine
		Unadjusted		Age and Sex Adjusted		Multivariatea
		HR (95% CI)	P Value	HR (95% CI)	P Value	HR (95% CI)	P Value
Total Stroke
Events	124
Q1		Reference		Reference		Reference
Q2		1.53 (0.82–2.87)	0.18	1.33 (0.70–2.49)	0.37	1.30 (0.69–2.45)	0.42
Q3		2.47 (1.39–4.38)	0.002	1.87 (1.04–3.33)	0.04	1.78 (0.99–3.19)	0.06
Q4		3.12 (1.78–5.44)	<0.001	2.11 (1.19–3.75)	0.01	2.01 (1.14–3.61)	0.02
Trend		1.46 (1.23–1.72)	<0.001	1.28 (1.08–1.52)	0.004	1.26 (1.06–1.50)	0.01
Per 1‐SDb		1.41 (1.22–1.63)	<0.001	1.26 (1.07–1.47)	0.005	1.23 (1.05–1.44)	0.01
Ischemic Stroke
Events	100
Q1		Reference		Reference		Reference
Q2		1.82 (0.88–3.75)	0.11	1.57 (0.76–3.25)	0.22	1.53 (0.74–3.16)	0.26
Q3		2.98 (1.52–5.82)	0.001	2.28 (1.16–4.48)	0.02	2.16 (1.09–4.26)	0.03
Q4		3.69 (1.92–7.08)	<0.001	2.56 (1.31–4.99)	0.01	2.39 (1.23–4.72)	0.01
Trend		1.51 (1.25–1.82)	<0.001	1.34 (1.11–1.62)	0.003	1.32 (1.09–1.59)	0.005
Per 1‐SDb		1.46 (1.25–1.71)	<0.001	1.31 (1.11–1.56)	0.002	1.29 (1.09–1.54)	0.004

CI indicates confidence interval; HR, hazard ratio; Q1, first quartile; Q4, fourth quartile.

^aAdjusted for age, sex, obesity, diabetes mellitus, hypertension, smoking, previous acute myocardial infarction, and atrial fibrillation.

^bLog‐transformed.