Table 3.

Hazard Ratios for Incident Stroke According to Plasma Levels of Methionine, Homocysteine, and Cysteine

	Total Stroke				Ischemic Stroke
	Q4 vs Q1	P Value	Per 1‐SDa	P Value	Q4 vs Q1	P Value	Per 1‐SDa	P Value
Plasma Met
Unadjusted	0.92 (0.54–1.57)	0.77	0.88 (0.74–1.06)	0.19	0.93 (0.51–1.67)	0.81	0.89 (0.73–1.09)	0.89
Model 1b	1.04 (0.61–1.78)	0.88	0.92 (0.76–1.09)	0.35	1.05 (0.58–1.89)	0.88	0.93 (0.76–1.13)	0.44
Model 2c	1.02 (0.60–1.75)	0.93	0.91 (0.76–1.08)	0.29	1.01 (0.55–1.83)	0.98	0.91 (0.75–1.11)	0.37
Model 3d	0.91 (0.51–1.62)	0.75	0.87 (0.73–1.06)	0.18	0.90 (0.48–1.75)	0.79	0.88 (0.71–1.08)	0.23
Plasma tHcy
Unadjusted	2.63 (1.55–4.44)	<0.001	1.40 (1.21–1.61)	<0.001	2.74 (1.55–4.83)	<0.001	1.44 (1.23–1.69)	<0.001
Model 1b	1.76 (1.01–3.04)	0.05	1.27 (1.08–1.50)	0.003	1.87 (1.03–3.38)	0.04	1.32 (1.11–1.59)	0.002
Model 2c	1.49 (0.85–2.60)	0.16	1.21 (1.02–1.45)	0.04	1.57 (0.86–2.87)	0.14	1.24 (1.03–1.54)	0.03
Model 3d	1.27 (0.72–2.28)	0.39	1.14 (0.95–1.39)	0.12	1.30 (0.71–2.43)	0.40	1.16 (0.97–1.44)	0.10
Plasma tCys
Unadjusted	3.38 (1.91–5.97)	<0.001	1.49 (1.26–1.76)	<0.001	2.88 (1.51–5.47)	<0.001	1.37 (1.14–1.65)	0.001
Model 1b	1.80 (0.99–3.29)	0.54	1.16 (0.96–1.41)	0.10	1.51 (0.77–2.97)	0.23	1.06 (0.87–1.31)	0.56
Model 2c	1.75 (0.95–3.21)	0.07	1.13 (0.93–1.36)	0.20	1.44 (0.7–2.85)	0.29	1.02 (0.83–1.26)	0.84
Model 3d	1.63 (0.89–3.01)	0.12	1.10 (0.91–1.33)	0.31	1.31 (0.66–2.61)	0.44	0.98 (0.81–1.22)	0.96

Met indicates methionine; Q1, first quartile; Q4, fourth quartile; tCyst, total cysteine; tHcy, total homocysteine.

^aLog‐transformed.

^bAdjusted for age and sex.

^cAdjusted for variables in model 1 plus obesity, diabetes mellitus, hypertension, smoking, previous myocardial infarction, and atrial fibrillation.

^dAdjusted for variables in model 2 plus plasma cystathionine.