Table 4.
Risk Association Between Plasma Cystathionine and Incident Stroke, When Separately Adjusted for Related 1‐Carbon Metabolites and Markers of B‐Vitamin Status
| Total Stroke | Ischemic Stroke | |||||||
|---|---|---|---|---|---|---|---|---|
| Q4 vs Q1 | P Value | Per 1‐SDa | P Value | Q4 vs Q1 | P Value | Per 1‐SDa | P Value | |
| Plasma cystathionine | ||||||||
| Model 2+Metb | 2.10 (1.16–3.85) | 0.01 | 1.23 (1.05–1.45) | 0.01 | 2.50 (1.26–5.08) | 0.01 | 1.30 (1.09–1.55) | 0.004 |
| Model 2+tHcyb | 1.92 (1.05–3.57) | 0.04 | 1.20 (1.03–1.43) | 0.04 | 2.26 (1.10–4.63) | 0.03 | 1.24 (1.03–1.50) | 0.03 |
| Model 2+tCysb | 1.96 (1.08–3.49) | 0.03 | 1.22 (1.04–1.42) | 0.03 | 2.34 (1.18–4.62) | 0.01 | 1.28 (1.07–1.53) | 0.01 |
| Model 2+folateb | 2.09 (1.17–3.76) | 0.01 | 1.24 (1.05–1.45) | 0.01 | 2.42 (1.23–4.81) | 0.01 | 1.29 (1.09–1.54) | 0.004 |
| Model 2+PLPb | 1.95 (1.06–3.59) | 0.03 | 1.21 (1.03–1.44) | 0.03 | 2.27 (1.13–4.64) | 0.02 | 1.26 (1.06–1.53) | 0.01 |
| Model 2+Cobb | 2.05 (1.04–4.06) | 0.04 | 1.26 (1.05–1.52) | 0.02 | 2.52 (1.12–5.66) | 0.02 | 1.33 (1.09–1.64) | 0.01 |
Cob indicates cobalamin (B12); Met, methionine; PLP, pyridoxal 5′‐phosphate; Q1, first quartile; Q4, fourth quartile; tCyst, total cysteine; tHcy, total homocysteine.
a
Log‐transformed.
b
Adjusted for age, sex, obesity, diabetes mellitus, hypertension, smoking, previous myocardial infarction, and atrial fibrillation.