Table 3.
Circadian Parameters in Cortical and Medullary Oxygenation, MAP, and HR During NOS Inhibition
| Cortex (%) n=6 | Medulla (%) n=7 | MAP (mm Hg) n=8 | HR (bpm) n=8 | |
|---|---|---|---|---|
| Mesor | ||||
| Con | 100.0 [99.8–100.2] | 100.0 [99.7–100.3] | 107.9 [107.4–108.5] | 338 [336–340] |
| Day 1 to 4 | 95.8 [95.0–96.6]a | 88.7 [88.0–89.4]a | 146.9 [146.3–147.5]a | 304 [302–305]a |
| Day 6 to 9 | 101.3 [100.1–102.6] | 90.2 [89.2–91.2]a | 152.2 [151.4–153.1]a | 303 [302–305]a |
| Day 11 to 14 | 104.9 [103.5–106.4]a | 81.7 [80.6–82.8]a | 165.1 [164.0–166.1]a | 326 [324–328]a |
| Amplitude | ||||
| Con | 5.7 [5.4–6.0] | 7.9 [7.5–8.4] | 4.0 [3.2–4.7] | 34 [31–36] |
| Day 1 to 4 | 6.0 [4.9–7.2] | 4.7 [3.7–5.7]a | 6.3 [5.5–7.2]a | 29 [27–31] |
| Day 6 to 9 | 5.3 [3.5–7.0] | 6.4 [4.9–7.8] | 3.7 [2.5–4.9] | 33 [31–35] |
| Day 11 to 14 | 5.4 [3.4–7.3] | 3.7 [2.2–5.3]a | 3.6 [2.1–5.1] | 26 [23–28]a |
| Acrophase (ZT hours) | ||||
| Con | 15.8 [15.2–16.4] | 16.9 [16.4–17.5] | 18.3 [17.1–19.5] | 16.3 [15.4–17.2] |
| Day 1 to 4 | 16.1 [15.2–17.1] | 15.6 [14.7–16.5] | 20.1 [19.2–21.0] | 16.4 [15.4–17.4] |
| Day 6 to 9 | 17.1 [16.3–18.0] | 16.5 [15.7–17.3] | 20.1 [18.2–22.0] | 16.7 [15.7–17.6] |
| Day 11 to 14 | 17.6 [16.5–18.6]a | 17.0 [15.8–18.2] | 22.3 [20.2–24.3]a | 16.6 [15.3–17.9] |
Data were analyzed by cosinor analysis (period=24 hours), lighting schedule; lights on at 6:00 am (Zeitgeber Time [ZT] 0), and lights off at 6:00 pm (ZT12). Mesor: circadian‐rhythm–adjusted mean; Acrophase: Peak time of cosine function (hours in ZT). All values shown as medians [95% CI]. CI indicates confidence interval; HR, heart rate; MAP, mean arterial pressure.
a
P<0.05 vs control.