Table 2.
Pharmacokinetic parameters after delsoline administration in mice.
| Parameters | Unit | ig (9 mg/kg) | ig (6 mg/kg) | ig (3 mg/kg) | iv (1 mg/kg) |
|---|---|---|---|---|---|
| AUC(0–t) | ng/mL∗h | 570.1 ± 147.5 | 271.9 ± 25.5 | 128.4 ± 52.2 | 241.4 ± 43.9 |
| AUC(0–∞) | ng/mL∗h | 571.0 ± 147.5 | 272.9 ± 25.1 | 129.9 ± 51.4 | 242.4 ± 44.0 |
| MRT(0–t) | H | 0.7 ± 0.1 | 0.7 ± 0.1 | 1.1 ± 0.2 | 0.3 ± 0.1 |
| MRT(0–∞) | H | 0.7 ± 0.1 | 0.7 ± 0.1 | 1.2 ± 0.3 | 0.4 ± 0.1 |
| t 1/2z | H | 1.3 ± 0.5 | 1.6 ± 0.7 | 1.7 ± 0.8 | 2.5 ± 0.7 |
| CLz/F | L/h/kg | 16.7 ± 4.4 | 22.1 ± 1.9 | 25.6 ± 8.3 | 4.2 ± 0.8 |
| V z/F | L/kg | 33.1 ± 22.7 | 51.1 ± 23.0 | 67.8 ± 50.3 | 15.4 ± 4.5 |
| C max | ng/mL | 573.2 ± 124.9 | 381.8 ± 70.8 | 146.0 ± 56.8 | 505.3 ± 69.5 |
| Bioavailability | 26.2% | 18.8% | 17.7% |